Ept7, a quantitative trait locus that controls estrogen-induced pituitary lactotroph hyperplasia in rat, is orthologous to a locus in humans that has been associated with numerous cancer types and common diseases

Kirsten L. Dennison; Aaron C. Chack; Maureen Peters Hickman; Quincy Eckert Harenda; James D. Shull

doi:10.1371/journal.pone.0204727

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Peer-reviewed

Research Article

Ept7, a quantitative trait locus that controls estrogen-induced pituitary lactotroph hyperplasia in rat, is orthologous to a locus in humans that has been associated with numerous cancer types and common diseases

Kirsten L. Dennison,

Roles Data curation, Formal analysis, Investigation, Project administration, Visualization, Writing – review & editing

Affiliation McArdle Laboratory for Cancer Research, Department of Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America
⨯
Aaron C. Chack,

Roles Formal analysis, Validation, Writing – review & editing

Affiliation McArdle Laboratory for Cancer Research, Department of Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America
⨯
Maureen Peters Hickman,

Roles Data curation, Formal analysis, Investigation, Project administration, Writing – review & editing

Affiliation McArdle Laboratory for Cancer Research, Department of Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America
⨯
Quincy Eckert Harenda,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation McArdle Laboratory for Cancer Research, Department of Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America
⨯
James D. Shull

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: shull@oncology.wisc.edu

Affiliations McArdle Laboratory for Cancer Research, Department of Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America, University of Wisconsin Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America

http://orcid.org/0000-0003-4537-5159

⨯

Ept7, a quantitative trait locus that controls estrogen-induced pituitary lactotroph hyperplasia in rat, is orthologous to a locus in humans that has been associated with numerous cancer types and common diseases

Kirsten L. Dennison,
Aaron C. Chack,
Maureen Peters Hickman,
Quincy Eckert Harenda,
James D. Shull

Published: September 27, 2018
https://doi.org/10.1371/journal.pone.0204727

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Pituitary gland
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Estrogens
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Breast cancer
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Pituitary tumors
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Prolactinoma
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Human genomics
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Cancer treatment
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Quantitative trait loci
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