In vitro and ex-vivo evaluation of topical formulations designed to minimize transdermal absorption of Vitamin K1

Ramina Nabiee; Barent Dubois; Laura Green; Ajay Sharma; Siu Fun Wong; Hamidreza Montazeri Aliabadi

doi:10.1371/journal.pone.0204531

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Open Access

Peer-reviewed

Research Article

In vitro and ex-vivo evaluation of topical formulations designed to minimize transdermal absorption of Vitamin K1

Ramina Nabiee,

Roles Investigation, Methodology, Validation, Writing – original draft

Affiliation Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, Irvine, California, United States

http://orcid.org/0000-0001-9806-8481

⨯
Barent Dubois,

Roles Data curation, Formal analysis, Methodology

Affiliation Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, Irvine, California, United States
⨯
Laura Green,

Roles Formal analysis, Methodology

Affiliation Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, Irvine, California, United States
⨯
Ajay Sharma,

Roles Data curation, Formal analysis, Methodology

Affiliation Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, Irvine, California, United States
⨯
Siu Fun Wong,

Roles Conceptualization, Writing – review & editing

Affiliation Department of Pharmacy Practice, Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, Irvine, California, United States
⨯
Hamidreza Montazeri Aliabadi

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Validation, Writing – review & editing

* E-mail: montazer@chapman.edu

Affiliations Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, Irvine, California, United States, Center for Targeted Drug Delivery, Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, Irvine, California, United States

http://orcid.org/0000-0002-8313-0657

⨯

In vitro and ex-vivo evaluation of topical formulations designed to minimize transdermal absorption of Vitamin K1

Ramina Nabiee,
Barent Dubois,
Laura Green,
Ajay Sharma,
Siu Fun Wong,
Hamidreza Montazeri Aliabadi

Published: October 5, 2018
https://doi.org/10.1371/journal.pone.0204531

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Vitamin K
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Ethers
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Lipids
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Surfactants
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Oils
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Toxicity
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