Association of metformin administration with gut microbiome dysbiosis in healthy volunteers

Ilze Elbere; Ineta Kalnina; Ivars Silamikelis; Ilze Konrade; Linda Zaharenko; Kristine Sekace; Ilze Radovica-Spalvina; Davids Fridmanis; Dita Gudra; Valdis Pirags; Janis Klovins

doi:10.1371/journal.pone.0204317

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Open Access

Peer-reviewed

Research Article

Association of metformin administration with gut microbiome dysbiosis in healthy volunteers

Ilze Elbere,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliation Latvian Biomedical Research and Study Centre, Riga, Latvia
⨯
Ineta Kalnina,

Roles Conceptualization, Investigation, Methodology, Project administration, Supervision, Validation, Writing – review & editing

Affiliation Latvian Biomedical Research and Study Centre, Riga, Latvia
⨯
Ivars Silamikelis,

Roles Data curation, Methodology, Software

Affiliation Latvian Biomedical Research and Study Centre, Riga, Latvia
⨯
Ilze Konrade,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Riga East Clinical University Hospital, Riga, Latvia
⨯
Linda Zaharenko,

Roles Conceptualization, Writing – review & editing

Affiliation Latvian Biomedical Research and Study Centre, Riga, Latvia
⨯
Kristine Sekace,

Roles Formal analysis, Methodology

Affiliation Latvian Biomedical Research and Study Centre, Riga, Latvia
⨯
Ilze Radovica-Spalvina,

Roles Conceptualization, Investigation, Validation

Affiliation Latvian Biomedical Research and Study Centre, Riga, Latvia
⨯
Davids Fridmanis,

Roles Conceptualization, Resources, Validation

Affiliation Latvian Biomedical Research and Study Centre, Riga, Latvia
⨯
Dita Gudra,

Roles Conceptualization, Investigation, Validation

Affiliation Latvian Biomedical Research and Study Centre, Riga, Latvia
⨯
Valdis Pirags,

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

Affiliations Latvian Biomedical Research and Study Centre, Riga, Latvia, Department of Endocrinology, Pauls Stradins Clinical University Hospital, Riga, Latvia
⨯
Janis Klovins

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: klovins@biomed.lu.lv

Affiliations Latvian Biomedical Research and Study Centre, Riga, Latvia, University of Latvia, Faculty of Biology, Riga, Latvia

http://orcid.org/0000-0001-8362-5505

⨯

Association of metformin administration with gut microbiome dysbiosis in healthy volunteers

Ilze Elbere,
Ineta Kalnina,
Ivars Silamikelis,
Ilze Konrade,
Linda Zaharenko,
Kristine Sekace,
Ilze Radovica-Spalvina,
Davids Fridmanis,
Dita Gudra,
Valdis Pirags

Published: September 27, 2018
https://doi.org/10.1371/journal.pone.0204317

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