Spatial statistical tools for genome-wide mutation cluster detection under a microarray probe sampling system

Bin Luo; Alanna K. Edge; Cornelia Tolg; Eva A. Turley; C. B. Dean; Kathleen A. Hill; R. J. Kulperger

doi:10.1371/journal.pone.0204156

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Open Access

Peer-reviewed

Research Article

Spatial statistical tools for genome-wide mutation cluster detection under a microarray probe sampling system

Bin Luo ,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

* E-mail: bluo4@uwo.ca (BL); cdean@uwaterloo.ca (CBD); khill22@uwo.ca (KAH); kulperger@stats.uwo.ca (RJK)

Affiliation Department of Statistical and Actuarial Sciences, Western University, London, Ontario, Canada

http://orcid.org/0000-0002-0608-9793

⨯
Alanna K. Edge,

Roles Formal analysis, Resources

Affiliation Department of Biology, Western University, London, Ontario, Canada
⨯
Cornelia Tolg,

Roles Resources

Affiliation London Regional Cancer Program, Lawson Health Research Institute, London, Ontario, Canada
⨯
Eva A. Turley,

Roles Resources, Supervision, Writing – review & editing

Affiliation London Regional Cancer Program, Lawson Health Research Institute, London, Ontario, Canada
⨯
C. B. Dean ,

Roles Funding acquisition, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: bluo4@uwo.ca (BL); cdean@uwaterloo.ca (CBD); khill22@uwo.ca (KAH); kulperger@stats.uwo.ca (RJK)

Affiliation Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada
⨯
Kathleen A. Hill ,

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: bluo4@uwo.ca (BL); cdean@uwaterloo.ca (CBD); khill22@uwo.ca (KAH); kulperger@stats.uwo.ca (RJK)

Affiliation Department of Biology, Western University, London, Ontario, Canada
⨯
R. J. Kulperger

Roles Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: bluo4@uwo.ca (BL); cdean@uwaterloo.ca (CBD); khill22@uwo.ca (KAH); kulperger@stats.uwo.ca (RJK)

Affiliation Department of Statistical and Actuarial Sciences, Western University, London, Ontario, Canada
⨯

Spatial statistical tools for genome-wide mutation cluster detection under a microarray probe sampling system

Bin Luo,
Alanna K. Edge,
Cornelia Tolg,
Eva A. Turley,
C. B. Dean,
Kathleen A. Hill,
R. J. Kulperger

Published: September 25, 2018
https://doi.org/10.1371/journal.pone.0204156

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Single nucleotide polymorphisms
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Test statistics
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Mutation detection
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Mammalian genomics
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Genotyping
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Genetic loci
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