Ethanol and unsaturated dietary fat induce unique patterns of hepatic ω-6 and ω-3 PUFA oxylipins in a mouse model of alcoholic liver disease

• Dennis R. Warner ,

  Contributed equally to this work with: Dennis R. Warner, Huilin Liu

  Roles Conceptualization, Formal analysis, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, Kentucky, United States of America

  http://orcid.org/0000-0002-5303-6870

  ⨯
• Huilin Liu ,

  Contributed equally to this work with: Dennis R. Warner, Huilin Liu

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, Kentucky, United States of America, College of Life Science, Jilin University, Changchun, China

  ⨯
• Shubha Ghosh Dastidar,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, Kentucky, United States of America

  ⨯
• Jeffrey B. Warner,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliations Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, Kentucky, United States of America, Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky, United States of America

  ⨯
• Md Aminul Islam Prodhan,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Chemistry, University of Louisville, Louisville, Kentucky, United States of America

  http://orcid.org/0000-0002-8707-0049

  ⨯
• Xinmin Yin,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Chemistry, University of Louisville, Louisville, Kentucky, United States of America

  ⨯
• Xiang Zhang,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliations Department of Chemistry, University of Louisville, Louisville, Kentucky, United States of America, University of Louisville Alcohol Center, University of Louisville School of Medicine, Louisville, Kentucky, United States of America, Hepatobiology & Toxicology Program, University of Louisville, Louisville, Kentucky, United States of America

  ⨯
• Ariel E. Feldstein,

  Roles Funding acquisition, Writing – review & editing

  Affiliation Division of Gastroenterology, Department of Pediatrics, University of California San Diego, San Diego, California, United States of America

  ⨯
• Bin Gao,

  Roles Writing – review & editing

  Affiliation Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Russell A. Prough,

  Roles Writing – review & editing

  Affiliations Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, Kentucky, United States of America, University of Louisville Alcohol Center, University of Louisville School of Medicine, Louisville, Kentucky, United States of America, Hepatobiology & Toxicology Program, University of Louisville, Louisville, Kentucky, United States of America

  ⨯
• Craig J. McClain,

  Roles Conceptualization, Funding acquisition, Resources, Writing – review & editing

  Affiliations Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, Kentucky, United States of America, Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky, United States of America, University of Louisville Alcohol Center, University of Louisville School of Medicine, Louisville, Kentucky, United States of America, Hepatobiology & Toxicology Program, University of Louisville, Louisville, Kentucky, United States of America, Robley Rex Veterans Medical Center, Louisville, Kentucky, United States of America

  ⨯
• Irina A. Kirpich

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: i0kirp01@louisville.edu

  Affiliations Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, Kentucky, United States of America, Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky, United States of America, University of Louisville Alcohol Center, University of Louisville School of Medicine, Louisville, Kentucky, United States of America, Hepatobiology & Toxicology Program, University of Louisville, Louisville, Kentucky, United States of America

  http://orcid.org/0000-0002-9545-6451

  ⨯