Improved glycemic control with minimal systemic metformin exposure: Effects of Metformin Delayed-Release (Metformin DR) targeting the lower bowel over 16 weeks in a randomized trial in subjects with type 2 diabetes

• Robert R. Henry ,

  Contributed equally to this work with: Robert R. Henry, Juan P. Frias, Brandon Walsh, Sharon Skare, John Hemming, Colleen Burns, Thomas A. Bicsak, Alain Baron, Mark Fineman

  Roles Conceptualization, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation University of California, San Diego, La Jolla, CA, United States of America

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• Juan P. Frias ,

  Contributed equally to this work with: Robert R. Henry, Juan P. Frias, Brandon Walsh, Sharon Skare, John Hemming, Colleen Burns, Thomas A. Bicsak, Alain Baron, Mark Fineman

  Roles Conceptualization, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation National Research Institute, Los Angeles, CA, United States of America

  ⨯
• Brandon Walsh ,

  Contributed equally to this work with: Robert R. Henry, Juan P. Frias, Brandon Walsh, Sharon Skare, John Hemming, Colleen Burns, Thomas A. Bicsak, Alain Baron, Mark Fineman

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: brandon.walsh@elcelyx.com

  Affiliation Elcelyx Therapeutics, Inc., San Diego, CA, United States of America

  http://orcid.org/0000-0003-4275-9245

  ⨯
• Sharon Skare ,

  Contributed equally to this work with: Robert R. Henry, Juan P. Frias, Brandon Walsh, Sharon Skare, John Hemming, Colleen Burns, Thomas A. Bicsak, Alain Baron, Mark Fineman

  Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Elcelyx Therapeutics, Inc., San Diego, CA, United States of America

  ⨯
• John Hemming ,

  Contributed equally to this work with: Robert R. Henry, Juan P. Frias, Brandon Walsh, Sharon Skare, John Hemming, Colleen Burns, Thomas A. Bicsak, Alain Baron, Mark Fineman

  Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Elcelyx Therapeutics, Inc., San Diego, CA, United States of America

  ⨯
• Colleen Burns ,

  Contributed equally to this work with: Robert R. Henry, Juan P. Frias, Brandon Walsh, Sharon Skare, John Hemming, Colleen Burns, Thomas A. Bicsak, Alain Baron, Mark Fineman

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Resources, Software, Writing – original draft, Writing – review & editing

  Affiliation Elcelyx Therapeutics, Inc., San Diego, CA, United States of America

  ⨯
• Thomas A. Bicsak ,

  Contributed equally to this work with: Robert R. Henry, Juan P. Frias, Brandon Walsh, Sharon Skare, John Hemming, Colleen Burns, Thomas A. Bicsak, Alain Baron, Mark Fineman

  Roles Conceptualization, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Elcelyx Therapeutics, Inc., San Diego, CA, United States of America

  ⨯
• Alain Baron ,

  Contributed equally to this work with: Robert R. Henry, Juan P. Frias, Brandon Walsh, Sharon Skare, John Hemming, Colleen Burns, Thomas A. Bicsak, Alain Baron, Mark Fineman

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  Affiliation Elcelyx Therapeutics, Inc., San Diego, CA, United States of America

  ⨯
• Mark Fineman

  Contributed equally to this work with: Robert R. Henry, Juan P. Frias, Brandon Walsh, Sharon Skare, John Hemming, Colleen Burns, Thomas A. Bicsak, Alain Baron, Mark Fineman

  Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Elcelyx Therapeutics, Inc., San Diego, CA, United States of America

  ⨯