Beta-adrenergic activation induces cardiac collapse by aggravating cardiomyocyte contractile dysfunction in bupivacaine intoxication

Jun Li; Ran Duan; Yingying Zhang; Xin Zhao; Yanxin Cheng; Yongxue Chen; Jinge Yuan; Hong Li; Jianping Zhang; Li Chu; Dengyun Xia; Senming Zhao

doi:10.1371/journal.pone.0203602

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Open Access

Peer-reviewed

Research Article

Beta-adrenergic activation induces cardiac collapse by aggravating cardiomyocyte contractile dysfunction in bupivacaine intoxication

Jun Li ,

Contributed equally to this work with: Jun Li, Ran Duan, Yingying Zhang

Roles Methodology

Affiliation Pain Medicine Center, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
⨯
Ran Duan ,

Contributed equally to this work with: Jun Li, Ran Duan, Yingying Zhang

Roles Investigation, Methodology

Affiliation Pain Medicine Center, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
⨯
Yingying Zhang ,

Contributed equally to this work with: Jun Li, Ran Duan, Yingying Zhang

Roles Investigation, Methodology

Affiliation Department of Anesthesiology, Hebei North University, Zhangjiakou, Hebei, China
⨯
Xin Zhao,

Roles Methodology

Affiliation Hepatopathy Department, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
⨯
Yanxin Cheng,

Roles Data curation

Affiliation Pain Medicine Center, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
⨯
Yongxue Chen,

Roles Formal analysis, Validation

Affiliation Department of Anesthesiology, Handan Center Hospital, Handan, Hebei, China
⨯
Jinge Yuan,

Roles Data curation

Affiliation Department of Anesthesiology, Handan Center Hospital, Handan, Hebei, China
⨯
Hong Li,

Roles Formal analysis, Investigation

Affiliation Pain Medicine Center, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
⨯
Jianping Zhang,

Roles Validation, Visualization

Affiliation Department of Pharmacology, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China
⨯
Li Chu,

Roles Supervision, Validation, Visualization

Affiliation Department of Pharmacology, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China
⨯
Dengyun Xia,

Roles Writing – review & editing

Affiliation Department of Anesthesiology, Hebei North University, Zhangjiakou, Hebei, China
⨯
Senming Zhao

Roles Conceptualization, Project administration, Supervision, Writing – original draft

* E-mail: senming63@163.com

Affiliation Pain Medicine Center, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China

http://orcid.org/0000-0002-1049-189X

⨯

Beta-adrenergic activation induces cardiac collapse by aggravating cardiomyocyte contractile dysfunction in bupivacaine intoxication

Jun Li,
Ran Duan,
Yingying Zhang,
Xin Zhao,
Yanxin Cheng,
Yongxue Chen,
Jinge Yuan,
Hong Li,
Jianping Zhang,
Li Chu

Published: October 1, 2018
https://doi.org/10.1371/journal.pone.0203602

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