Prodrugs for colon-restricted delivery: Design, synthesis, and in vivo evaluation of colony stimulating factor 1 receptor (CSF1R) inhibitors

• Dawn M. George ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: dawn.george@abbvie.com

  Affiliation Immunology Discovery, AbbVie Bioresearch Center, Worcester, Massachusetts, United States of America

  http://orcid.org/0000-0002-7129-9092

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• Raymond J. Huntley,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Chemistry, Immunology Discovery, AbbVie Bioresearch Center, Worcester, Massachusetts, United States of America

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• Kevin Cusack,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Department of Chemistry, Immunology Discovery, AbbVie Bioresearch Center, Worcester, Massachusetts, United States of America

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• David B. Duignan,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Drug Metabolism, Pharmacokinetics & Bioanalysis, AbbVie Bioresearch Center, Worcester, Massachusetts, United States of America

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• Michael Hoemann,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Department of Chemistry, Immunology Discovery, AbbVie Bioresearch Center, Worcester, Massachusetts, United States of America

  http://orcid.org/0000-0001-9259-7702

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• Jacqueline Loud,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Pharmacology, Immunology Discovery, AbbVie Bioresearch Center, Worcester, Massachusetts, United States of America

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• Regina Mario,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Pharmacology, Immunology Discovery, AbbVie Bioresearch Center, Worcester, Massachusetts, United States of America

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• Terry Melim,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Pharmacology, Immunology Discovery, AbbVie Bioresearch Center, Worcester, Massachusetts, United States of America

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• Kelly Mullen,

  Roles Conceptualization, Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Chemistry, Immunology Discovery, AbbVie Bioresearch Center, Worcester, Massachusetts, United States of America

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• Gagandeep Somal,

  Roles Conceptualization, Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Chemistry, Immunology Discovery, AbbVie Bioresearch Center, Worcester, Massachusetts, United States of America

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• Lu Wang,

  Roles Conceptualization, Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Chemistry, Immunology Discovery, AbbVie Bioresearch Center, Worcester, Massachusetts, United States of America

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• Jeremy J. Edmunds

  Roles Conceptualization, Formal analysis, Project administration, Supervision, Writing – review & editing

  Affiliation Department of Chemistry, Immunology Discovery, AbbVie Bioresearch Center, Worcester, Massachusetts, United States of America

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