Effects of four weeks intermittent hypoxia intervention on glucose homeostasis, insulin sensitivity, GLUT4 translocation, insulin receptor phosphorylation, and Akt activity in skeletal muscle of obese mice with type 2 diabetes

Yun Wang; Li Wen; Shi Zhou; Yong Zhang; Xin-Hao Wang; You-Yu He; Allan Davie; Suzanne Broadbent

doi:10.1371/journal.pone.0203551

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Open Access

Peer-reviewed

Research Article

Effects of four weeks intermittent hypoxia intervention on glucose homeostasis, insulin sensitivity, GLUT4 translocation, insulin receptor phosphorylation, and Akt activity in skeletal muscle of obese mice with type 2 diabetes

Yun Wang,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft

Affiliation School of Health and Human Sciences, Southern Cross University, Lismore, Australia
⨯
Li Wen ,

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

* E-mail: shi.zhou@scu.edu.au(SZ); wenli34@hotmail.com(LW)

Affiliation Key Laboratory of Exercise Physiology and Sports Medicine, Tianjin University of Sport, Tianjin, China
⨯
Shi Zhou ,

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: shi.zhou@scu.edu.au(SZ); wenli34@hotmail.com(LW)

Affiliation School of Health and Human Sciences, Southern Cross University, Lismore, Australia

http://orcid.org/0000-0001-9038-5984

⨯
Yong Zhang,

Roles Supervision, Writing – review & editing

Affiliation Key Laboratory of Exercise Physiology and Sports Medicine, Tianjin University of Sport, Tianjin, China
⨯
Xin-Hao Wang,

Roles Investigation

Affiliation Department of Health and Exercise Science, Tianjin University of Sport, Tianjin, China
⨯
You-Yu He,

Roles Investigation

Affiliation Department of Health and Exercise Science, Tianjin University of Sport, Tianjin, China
⨯
Allan Davie,

Roles Supervision, Writing – review & editing

Affiliation School of Health and Human Sciences, Southern Cross University, Lismore, Australia
⨯
Suzanne Broadbent

Roles Supervision, Writing – review & editing

Current address: School of Health and Sports Sciences, University of the Sunshine Coast, Maroochydore, Australia

Affiliation School of Health and Human Sciences, Southern Cross University, Lismore, Australia
⨯

Effects of four weeks intermittent hypoxia intervention on glucose homeostasis, insulin sensitivity, GLUT4 translocation, insulin receptor phosphorylation, and Akt activity in skeletal muscle of obese mice with type 2 diabetes

Yun Wang,
Li Wen,
Shi Zhou,
Yong Zhang,
Xin-Hao Wang,
You-Yu He,
Allan Davie,
Suzanne Broadbent

Published: September 10, 2018
https://doi.org/10.1371/journal.pone.0203551

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Skeletal muscles
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Insulin
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Hypoxia
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Glucose
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Diabetes mellitus
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Type 2 diabetes
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Phosphorylation
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Medical hypoxia
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