Prognostic utility of serum free light chain ratios and heavy-light chain ratios in multiple myeloma in three PETHEMA/GEM phase III clinical trials

• Lucia Lopez-Anglada ,

  Roles Conceptualization, Data curation, Writing – original draft, Writing – review & editing

  * E-mail: jmarti01@ucm.es (JML); lucia.lopezanglada@gmail.com (LLA)

  Affiliation Hematology Department, Hospital Universitario 12 de Octubre, CIBERONC, Madrid, Spain

  http://orcid.org/0000-0003-1727-8546

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• Cecilia Cueto-Felgueroso,

  Roles Data curation, Investigation, Methodology

  Affiliation Clinical Biochemistry Department, Hospital Universitario 12 de Octubre, Madrid, Spain

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• Laura Rosiñol,

  Roles Data curation, Supervision, Writing – review & editing

  Affiliation Hematology Department, Hospital Clinic, Institut d'Investigacions Biomédiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain

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• Albert Oriol,

  Roles Writing – review & editing

  Affiliation Hospital Germans i Trials, Barcelona, Spain

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• Ana Isabel Teruel,

  Roles Data curation

  Affiliation Hematology Department, Hospital Clínico de Valencia, Valencia, Spain

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• Ana Lopez de la Guia,

  Roles Data curation

  Affiliation Hematology Department, Hospital La Paz, Madrid, Spain

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• Enrique Bengoechea,

  Roles Data curation

  Affiliation Hematology Department, Hospital de Donostia, San Sebastian, Spain

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• Luis Palomera,

  Roles Data curation

  Affiliation Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain

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• Felipe de Arriba,

  Roles Data curation

  Affiliation Hospital Morales Meseguer, Murcia, Spain

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• Jose Mariano Hernandez,

  Roles Data curation

  Affiliation Hematology Department, Hospital General de Segovia, Segovia, Spain

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• Miquel Granell,

  Roles Data curation

  Affiliation Haematology, Hospital Univarsitari de la Santa Creu i Sant Pau, Barcelona,Spain

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• Francisco Javier Peñalver,

  Roles Data curation

  Affiliation Haematology Department, Hospital Universitario Fundacion Alcorcon, Madrid, Spain

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• Ramon Garcia-Sanz,

  Roles Data curation, Supervision

  Affiliation Hematology Department, Hospital Universitario de Salamanca-IBSAL, IBMCC-CSIC, Salamanca, Spain

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• Juan Besalduch,

  Roles Data curation

  Affiliation Haematology Department, Hospital Univarsitari Son Espases, Mallorca, Spain

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• Yolanda Gonzalez,

  Roles Data curation

  Affiliation Haematology Department, Institutd’Oncologia Dr Josep Trueta de Girona, Girona, Spain

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• Rafael Benigno Martinez,

  Roles Data curation

  Affiliation Haematology Department, Hospital Universitario San Carlos, Madrid, Spain

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• Miguel Teodoro Hernandez,

  Roles Data curation

  Affiliation Haematology Department, Hospital Universitario de Canarias, Tenerife, Spain

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• Norma C. Gutierrez,

  Roles Data curation

  Affiliation Hematology Department, Hospital Clinic, Institut d'Investigacions Biomédiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain

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• Paloma Puerta,

  Roles Data curation, Methodology

  Affiliation Clinical Biochemistry Department, Hospital Universitario 12 de Octubre, Madrid, Spain

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• Antonio Valeri,

  Roles Data curation

  Affiliation Hematology Department, Hospital Universitario 12 de Octubre, CIBERONC, Madrid, Spain

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• Bruno Paiva,

  Roles Data curation, Supervision

  Affiliation Haematology Department, Clínica Universitaria de Navarra/ CIMA,IDISNA, CIBERONC,Pamplona, SPAIN

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• Joan Blade,

  Roles Funding acquisition, Supervision, Writing – review & editing

  Affiliation Hospital Germans i Trials, Barcelona, Spain

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• Maria-Victoria Mateos,

  Roles Validation, Writing – review & editing

  Affiliation Hematology Department, Hospital Clinic, Institut d'Investigacions Biomédiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain

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• Jesus San Miguel,

  Roles Supervision, Writing – review & editing

  Affiliation Haematology Department, Clínica Universitaria de Navarra/ CIMA,IDISNA, CIBERONC,Pamplona, SPAIN

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• Juan Jose Lahuerta ,

  Roles Conceptualization, Funding acquisition, Supervision, Validation, Writing – original draft, Writing – review & editing

  ¶‡ These authors are joint co-chairs on this study.

  Affiliation Hematology Department, Hospital Universitario 12 de Octubre, CIBERONC, Madrid, Spain

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• Joaquin Martinez-Lopez ,

  Roles Conceptualization, Funding acquisition, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: jmarti01@ucm.es (JML); lucia.lopezanglada@gmail.com (LLA)

  ¶‡ These authors are joint co-chairs on this study.

  Affiliation Hematology Department, Hospital Universitario 12 de Octubre, CIBERONC, Madrid, Spain

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•  [ ... ],
• on behalf of the GEM (Grupo Español de MM)/PETHEMA (Programa para el Estudio de la Terapéutica en Hemopatías Malignas) Cooperative Study Group

  ¶Membership of the GEM (Grupo Español de MM)/PETHEMA (Programa para el Estudio de la Terapéutica en Hemopatías Malignas) Cooperative Study Group^ is provided in the Acknowledgments.

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