Increased MMP activity in curved geometries disrupts the endothelial cell glycocalyx creating a proinflammatory environment

• Scott Cooper,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Chemical Engineering, McGill University, Montréal, Quebec, Canada

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• Alexander Emmott,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Department of Chemical Engineering, McGill University, Montréal, Quebec, Canada, Montreal Heart Institute, Montréal, Quebec, Canada

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• Karli K. McDonald,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology

  Affiliation Department of Chemical Engineering, McGill University, Montréal, Quebec, Canada

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• Marc-Antoine Campeau,

  Roles Investigation, Visualization, Writing – review & editing

  Affiliation Department of Chemical Engineering, McGill University, Montréal, Quebec, Canada

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• Richard L. Leask

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing

  * E-mail: Richard.leask@mail.mcgill.ca

  Affiliations Department of Chemical Engineering, McGill University, Montréal, Quebec, Canada, Montreal Heart Institute, Montréal, Quebec, Canada

  http://orcid.org/0000-0002-3649-5127

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