FGF21 increases water intake, urine output and blood pressure in rats

Tod Turner; Xian Chen; Matthew Zahner; Alan Opsahl; George DeMarco; Magalie Boucher; Bryan Goodwin; Mylène Perreault

doi:10.1371/journal.pone.0202182

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Open Access

Peer-reviewed

Research Article

FGF21 increases water intake, urine output and blood pressure in rats

Tod Turner,

Roles Conceptualization, Methodology

Current address: Abbvie, Cambridge, Massachusetts, United States of America

Affiliation Internal Medicine Research Unit, Pfizer Inc, Cambridge, Massachusetts, United States of America
⨯
Xian Chen,

Roles Conceptualization, Formal analysis, Methodology

Affiliation Comparative Medicine, Pfizer Inc, Cambridge, Massachusetts, United States of America
⨯
Matthew Zahner,

Roles Conceptualization, Formal analysis, Methodology, Validation, Writing – original draft, Writing – review & editing

Current address: East Tennessee State University, Johnson City, Tennessee, United States of America

Affiliation Drug Safety Research and Development (DSRD), Pfizer Inc, Groton, Connecticut, United States of America
⨯
Alan Opsahl,

Roles Formal analysis, Methodology

Affiliation Drug Safety Research and Development (DSRD), Pfizer Inc, Groton, Connecticut, United States of America
⨯
George DeMarco,

Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

Current address: University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Affiliation Comparative Medicine, Pfizer Inc, Cambridge, Massachusetts, United States of America
⨯
Magalie Boucher,

Roles Formal analysis, Methodology, Writing – original draft, Writing – review & editing

Affiliation Drug Safety Research and Development (DSRD), Pfizer Inc, Cambridge, Massachusetts, United States of America
⨯
Bryan Goodwin,

Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

Current address: Enanta, Watertown Massachusetts, United States of America

Affiliation Internal Medicine Research Unit, Pfizer Inc, Cambridge, Massachusetts, United States of America
⨯
Mylène Perreault

Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: mylene@synlogictx.com

Current address: Synlogic, Cambridge, Massachusetts, United States of America

Affiliation Internal Medicine Research Unit, Pfizer Inc, Cambridge, Massachusetts, United States of America

http://orcid.org/0000-0002-3644-6413

⨯

FGF21 increases water intake, urine output and blood pressure in rats

Tod Turner,
Xian Chen,
Matthew Zahner,
Alan Opsahl,
George DeMarco,
Magalie Boucher,
Bryan Goodwin,
Mylène Perreault

Published: August 14, 2018
https://doi.org/10.1371/journal.pone.0202182

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Urine
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Heart rate
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