High glucose and low specific cell growth but not mild hypothermia improve specific r-protein productivity in chemostat culture of CHO cells

• Mauricio Vergara,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations School of Biochemical Engineering, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile, Institute of Chemistry, Pontificia Universidad Católica de Valparaíso, Valparaiso, Chile

  ⨯
• Mauro Torres,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation School of Biochemical Engineering, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile

  ⨯
• Andrea Müller,

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Writing – original draft

  Affiliation School of Biochemical Engineering, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile

  ⨯
• Verónica Avello,

  Roles Investigation, Methodology, Supervision, Validation, Writing – original draft

  Affiliations School of Biochemical Engineering, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile, Center of Biotechnology, Universidad Técnica Federico Santa María, Valparaíso, Chile

  ⨯
• Cristian Acevedo,

  Roles Conceptualization, Formal analysis, Investigation, Software, Writing – review & editing

  Affiliations Center of Biotechnology, Universidad Técnica Federico Santa María, Valparaíso, Chile, Institute of Physics, Universidad Técnica Federico Santa María, Valparaíso, Chile

  ⨯
• Julio Berrios,

  Roles Conceptualization, Investigation, Supervision, Writing – review & editing

  Affiliation School of Biochemical Engineering, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile

  ⨯
• Juan G. Reyes,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Writing – original draft, Writing – review & editing

  Affiliation Institute of Chemistry, Pontificia Universidad Católica de Valparaíso, Valparaiso, Chile

  ⨯
• Norma A. Valdez-Cruz,

  Roles Writing – review & editing

  Affiliation Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, México

  ⨯
• Claudia Altamirano

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: claudia.altamirano@pucv.cl

  Affiliations School of Biochemical Engineering, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile, Regional Center for Healthy Food Studies (CREAS) R17A10001, CONICYT REGIONAL, GORE Valparaiso, Chile

  http://orcid.org/0000-0003-4448-9074

  ⨯