The metabolomic plasma profile of myeloma patients is considerably different from healthy subjects and reveals potential new therapeutic targets

• Normann Steiner ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: normann.steiner@i-med.ac.at

  Affiliation Laboratory for Tumor Biology & Angiogenesis, Department of Internal Medicine V (Hematology and Medical Oncology), Medical University of Innsbruck, Innsbruck, Austria

  http://orcid.org/0000-0001-9829-1309

  ⨯
• Udo Müller,

  Roles Formal analysis, Methodology, Software, Visualization, Writing – original draft

  Affiliation Biocrates Life Sciences AG, Innsbruck, Austria

  ⨯
• Roman Hajek,

  Roles Data curation, Writing – review & editing

  Affiliations Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic, Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic

  ⨯
• Sabina Sevcikova,

  Roles Data curation, Writing – review & editing

  Affiliations Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic, Department of Clinical Hematology, University Hospital Brno, Brno, Czech Republic

  http://orcid.org/0000-0002-7194-6771

  ⨯
• Bojana Borjan,

  Roles Data curation, Writing – original draft

  Affiliation Laboratory for Tumor Biology & Angiogenesis, Department of Internal Medicine V (Hematology and Medical Oncology), Medical University of Innsbruck, Innsbruck, Austria

  ⨯
• Karin Jöhrer,

  Roles Data curation, Writing – review & editing

  Affiliations Tyrolean Cancer Research Institute, Innsbruck, Austria, Salzburg Cancer Research Institute, Laboratory for Immunological and Molecular Cancer Research, Salzburg, Austria

  ⨯
• Georg Göbel,

  Roles Formal analysis, Project administration, Writing – review & editing

  Affiliation Department of Medical Statistics, Informatics and Health Economics, Medical University of Innsbruck, Innsbruck, Austria

  ⨯
• Andreas Pircher ,

  Contributed equally to this work with: Andreas Pircher, Eberhard Gunsilius

  Roles Conceptualization, Project administration, Writing – review & editing

  Affiliation Laboratory for Tumor Biology & Angiogenesis, Department of Internal Medicine V (Hematology and Medical Oncology), Medical University of Innsbruck, Innsbruck, Austria

  ⨯
• Eberhard Gunsilius

  Contributed equally to this work with: Andreas Pircher, Eberhard Gunsilius

  Roles Supervision, Writing – review & editing

  Affiliation Laboratory for Tumor Biology & Angiogenesis, Department of Internal Medicine V (Hematology and Medical Oncology), Medical University of Innsbruck, Innsbruck, Austria

  ⨯