Truncations of the titin Z-disc predispose to a heart failure with preserved ejection phenotype in the context of pressure overload

Lei Ye; Liping Su; Chenxu Wang; Szejie Loo; Guizhen Tee; Shihua Tan; Sandar Win Khin; Shijie Ko; Boyang Su; Stuart A. Cook

doi:10.1371/journal.pone.0201498

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Open Access

Peer-reviewed

Research Article

Truncations of the titin Z-disc predispose to a heart failure with preserved ejection phenotype in the context of pressure overload

Lei Ye ,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

* E-mail: ye.lei@nhcs.com.sg

Affiliation National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore

http://orcid.org/0000-0001-5039-6224

⨯
Liping Su,

Roles Investigation, Methodology

Affiliation National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore
⨯
Chenxu Wang,

Roles Investigation, Methodology

Affiliation National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore
⨯
Szejie Loo,

Roles Investigation, Methodology

Affiliation National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore
⨯
Guizhen Tee,

Roles Investigation, Methodology

Affiliation National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore
⨯
Shihua Tan,

Roles Investigation, Methodology

Affiliation National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore
⨯
Sandar Win Khin,

Roles Methodology

Affiliation National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore
⨯
Shijie Ko,

Roles Methodology

Affiliation Duke-National University of Singapore Medical School, Singapore, Singapore
⨯
Boyang Su,

Roles Investigation, Methodology

Affiliation National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore
⨯
Stuart A. Cook

Roles Conceptualization, Project administration, Resources, Writing – review & editing

Affiliations National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore, Duke-National University of Singapore Medical School, Singapore, Singapore, National Heart and Lung Institute, Imperial College, London, United Kingdom
⨯

Truncations of the titin Z-disc predispose to a heart failure with preserved ejection phenotype in the context of pressure overload

Lei Ye,
Liping Su,
Chenxu Wang,
Szejie Loo,
Guizhen Tee,
Shihua Tan,
Sandar Win Khin,
Shijie Ko,
Boyang Su,
Stuart A. Cook

Published: July 31, 2018
https://doi.org/10.1371/journal.pone.0201498

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