Mathematical modeling of disease dynamics in SDHB- and SDHD-related paraganglioma: Further step in understanding hereditary tumor differences and future therapeutic strategies

Dominique Barbolosi; Joakim Crona; Raphaël Serre; Karel Pacak; David Taieb

doi:10.1371/journal.pone.0201303

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Open Access

Peer-reviewed

Research Article

Mathematical modeling of disease dynamics in SDHB- and SDHD-related paraganglioma: Further step in understanding hereditary tumor differences and future therapeutic strategies

Dominique Barbolosi ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: david.taieb@ap-hm.fr (DT); dominique.barbolosi@univ-amu.fr (DB)

Affiliations Aix-Marseille University, School of Pharmacy of Marseille, Simulation & Modelling: Adaptive Response for Therapeutics in Cancer (SMARTc), Marseille, France, INSERM UMR U1068, CNRS UMR 7258, Aix-Marseille University, Cancer Research Center of Marseille, Marseille, France
⨯
Joakim Crona,

Roles Conceptualization, Validation, Writing – original draft

Affiliation Department of Medical Sciences, Uppsala University, Uppsala, Sweden
⨯
Raphaël Serre,

Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – original draft

Affiliations Aix-Marseille University, School of Pharmacy of Marseille, Simulation & Modelling: Adaptive Response for Therapeutics in Cancer (SMARTc), Marseille, France, INSERM UMR U1068, CNRS UMR 7258, Aix-Marseille University, Cancer Research Center of Marseille, Marseille, France
⨯
Karel Pacak,

Roles Conceptualization, Formal analysis, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliation Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States of America
⨯
David Taieb

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: david.taieb@ap-hm.fr (DT); dominique.barbolosi@univ-amu.fr (DB)

Affiliations INSERM UMR U1068, CNRS UMR 7258, Aix-Marseille University, Cancer Research Center of Marseille, Marseille, France, Aix-Marseille University, Department of Nuclear Medicine, La Timone University Hospital, European Center for Research in Medical Imaging, Marseille, France
⨯

Mathematical modeling of disease dynamics in SDHB- and SDHD-related paraganglioma: Further step in understanding hereditary tumor differences and future therapeutic strategies

Dominique Barbolosi,
Joakim Crona,
Raphaël Serre,
Karel Pacak,
David Taieb

Published: August 14, 2018
https://doi.org/10.1371/journal.pone.0201303

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