Exposure to nicotine-derived nitrosamine ketone and arecoline synergistically facilitates tumor aggressiveness via overexpression of epidermal growth factor receptor and its downstream signaling in head and neck squamous cell carcinoma

• Shih-Hsien Yang,

  Roles Conceptualization, Data curation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, Department of Medical Administration Office, National Defense Medical Center & Tri-Service General Hospital Beitou Branch, Taipei, Taiwan

  http://orcid.org/0000-0001-8224-7098

  ⨯
• Tsai-Yu Lee,

  Roles Conceptualization, Formal analysis, Investigation

  Affiliations Tri-Service General Hospital Songshan Branch, National Defense Medical Center, Division of Colon and Rectum Surgery, Department of Surgery, Taipei, Taiwan, Tri-Service General Hospital, National Defense Medical Center, Division of Colon and Rectum Surgery, Department of Surgery, Taipei, Taiwan

  ⨯
• Chun An Ho,

  Roles Data curation, Formal analysis, Methodology, Software

  Affiliation Department of Pathology, National Defense Medical Center & Tri-Service General Hospital, Taipei, Taiwan

  ⨯
• Chin-Yuh Yang,

  Roles Conceptualization, Methodology, Software

  Affiliation Department of Dentistry, Cheng Hsin Hospital, Taipei, Taiwan

  ⨯
• Wen-Yen Huang,

  Roles Conceptualization, Data curation, Formal analysis, Supervision, Validation

  Affiliations Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan

  ⨯
• Yu-Chun Lin,

  Roles Conceptualization, Project administration, Software, Visualization

  Affiliation Department of Pathology, National Defense Medical Center & Tri-Service General Hospital, Taipei, Taiwan

  ⨯
• Shin Nieh,

  Roles Resources, Software, Supervision, Visualization, Writing – review & editing

  Affiliation Department of Pathology, National Defense Medical Center & Tri-Service General Hospital, Taipei, Taiwan

  ⨯
• Yaoh-Shiang Lin ,

  Contributed equally to this work with: Yaoh-Shiang Lin, Su-Feng Chen, Fu-Huang Lin

  Roles Conceptualization, Formal analysis, Project administration, Supervision, Validation, Visualization, Writing – original draft

  * E-mail: noldling@ms10.hinet.net (FH Lin); yaohshiang@gmail.com (YS Lin); su374065@gmail.com (SF Chen)

  Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

  ⨯
• Su-Feng Chen ,

  Contributed equally to this work with: Yaoh-Shiang Lin, Su-Feng Chen, Fu-Huang Lin

  Roles Data curation, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: noldling@ms10.hinet.net (FH Lin); yaohshiang@gmail.com (YS Lin); su374065@gmail.com (SF Chen)

  Affiliation Department of Dental Hygiene and School of Dentistry, China Medical University, Taichung, Taiwan

  ⨯
• Fu-Huang Lin

  Contributed equally to this work with: Yaoh-Shiang Lin, Su-Feng Chen, Fu-Huang Lin

  Roles Investigation, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: noldling@ms10.hinet.net (FH Lin); yaohshiang@gmail.com (YS Lin); su374065@gmail.com (SF Chen)

  Affiliation School of Public Health, National Defense Medical Center, Taipei, Taiwan

  ⨯