The mRNA cap methyltransferase gene TbCMT1 is not essential in vitro but is a virulence factor in vivo for bloodstream form Trypanosoma brucei

Anna Kelner; Michele Tinti; Maria Lucia S. Guther; Bernardo J. Foth; Lia Chappell; Matthew Berriman; Victoria Haigh Cowling; Michael A. J. Ferguson

doi:10.1371/journal.pone.0201263

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Research Article

The mRNA cap methyltransferase gene TbCMT1 is not essential in vitro but is a virulence factor in vivo for bloodstream form Trypanosoma brucei

Anna Kelner ,

Contributed equally to this work with: Anna Kelner, Michele Tinti

Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯
Michele Tinti ,

Contributed equally to this work with: Anna Kelner, Michele Tinti

Roles Formal analysis, Visualization, Writing – original draft, Writing – review & editing

Affiliation Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom

http://orcid.org/0000-0002-0051-017X

⨯
Maria Lucia S. Guther,

Roles Investigation, Supervision

Affiliation Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯
Bernardo J. Foth,

Roles Formal analysis

Affiliation The Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Lia Chappell,

Roles Formal analysis, Investigation

Affiliation The Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Matthew Berriman,

Roles Formal analysis

Affiliation The Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Victoria Haigh Cowling ,

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: m.a.j.ferguson@dundee.ac.uk (MAJF); v.h.cowling@dundee.ac.uk (VHC)

Affiliation Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯
Michael A. J. Ferguson

Roles Conceptualization, Funding acquisition, Writing – original draft, Writing – review & editing

* E-mail: m.a.j.ferguson@dundee.ac.uk (MAJF); v.h.cowling@dundee.ac.uk (VHC)

Affiliation Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom

http://orcid.org/0000-0003-1321-8714

⨯

The mRNA cap methyltransferase gene TbCMT1 is not essential in vitro but is a virulence factor in vivo for bloodstream form Trypanosoma brucei

Anna Kelner,
Michele Tinti,
Maria Lucia S. Guther,
Bernardo J. Foth,
Lia Chappell,
Matthew Berriman,
Victoria Haigh Cowling,
Michael A. J. Ferguson

Published: July 24, 2018
https://doi.org/10.1371/journal.pone.0201263

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Trypanosoma brucei gambiense
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