Targeting the Mincle and TLR3 receptor using the dual agonist cationic adjuvant formulation 9 (CAF09) induces humoral and polyfunctional memory T cell responses in calves

Aneesh Thakur; Athina Andrea; Heidi Mikkelsen; Joshua S. Woodworth; Peter Andersen; Gregers Jungersen; Claus Aagaard

doi:10.1371/journal.pone.0201253

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Open Access

Peer-reviewed

Research Article

Targeting the Mincle and TLR3 receptor using the dual agonist cationic adjuvant formulation 9 (CAF09) induces humoral and polyfunctional memory T cell responses in calves

Aneesh Thakur,

Roles Data curation, Formal analysis, Investigation, Writing – original draft

Current address: Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Affiliation Section for Immunology and Vaccinology, National Veterinary Institute, Technical University of Denmark, Kgs. Lyngby, Denmark
⨯
Athina Andrea,

Roles Data curation, Formal analysis, Methodology

Current address: Department of Science and Environment, Roskilde University, Roskilde, Denmark

Affiliation Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark

http://orcid.org/0000-0002-1498-1220

⨯
Heidi Mikkelsen,

Roles Data curation, Methodology

Current address: Analytical Development, ALK-Abelló, Hoersholm, Denmark

Affiliation Section for Immunology and Vaccinology, National Veterinary Institute, Technical University of Denmark, Kgs. Lyngby, Denmark
⨯
Joshua S. Woodworth,

Roles Formal analysis, Supervision

Affiliation Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
⨯
Peter Andersen,

Roles Conceptualization, Funding acquisition

Affiliation Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
⨯
Gregers Jungersen ,

Roles Data curation, Funding acquisition, Project administration, Supervision

* E-mail: caa@ssi.dk (CA); grju@dtu.dk (GJ)

Current address: DTU Bioengineering, Technical University of Denmark, Kgs. Lyngby, Denmark

Affiliation Section for Immunology and Vaccinology, National Veterinary Institute, Technical University of Denmark, Kgs. Lyngby, Denmark

http://orcid.org/0000-0003-3147-6960

⨯
Claus Aagaard

Roles Conceptualization, Project administration, Supervision, Writing – original draft

* E-mail: caa@ssi.dk (CA); grju@dtu.dk (GJ)

Affiliation Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark

http://orcid.org/0000-0001-6433-3056

⨯

Targeting the Mincle and TLR3 receptor using the dual agonist cationic adjuvant formulation 9 (CAF09) induces humoral and polyfunctional memory T cell responses in calves

Aneesh Thakur,
Athina Andrea,
Heidi Mikkelsen,
Joshua S. Woodworth,
Peter Andersen,
Gregers Jungersen,
Claus Aagaard

Published: July 31, 2018
https://doi.org/10.1371/journal.pone.0201253

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