T cell LFA-1-induced proinflammatory mRNA stabilization is mediated by the p38 pathway kinase MK2 in a process regulated by hnRNPs C, H1 and K

Gautham K. Rao; Albert Wong; Mark Collinge; Joseph Sarhan; Timur O. Yarovinsky; Vinod S. Ramgolam; Matthias Gaestel; Ruggero Pardi; Jeffrey R. Bender

doi:10.1371/journal.pone.0201103

Loading metrics

Open Access

Peer-reviewed

Research Article

T cell LFA-1-induced proinflammatory mRNA stabilization is mediated by the p38 pathway kinase MK2 in a process regulated by hnRNPs C, H1 and K

Gautham K. Rao ,

Contributed equally to this work with: Gautham K. Rao, Albert Wong

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft

Affiliations Department of Internal Medicine, Section of Cardiovascular Medicine, Cardiovascular Research Center, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America, Raymond and Beverly Sackler Foundation Cardiovascular Laboratory, New Haven, Connecticut, United States of America
⨯
Albert Wong ,

Contributed equally to this work with: Gautham K. Rao, Albert Wong

Roles Data curation, Formal analysis, Investigation, Validation, Writing – original draft

Affiliations Raymond and Beverly Sackler Foundation Cardiovascular Laboratory, New Haven, Connecticut, United States of America, Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Mark Collinge,

Roles Conceptualization, Data curation, Formal analysis, Methodology

Affiliations Department of Internal Medicine, Section of Cardiovascular Medicine, Cardiovascular Research Center, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America, Raymond and Beverly Sackler Foundation Cardiovascular Laboratory, New Haven, Connecticut, United States of America
⨯
Joseph Sarhan,

Roles Data curation, Investigation

Affiliations Department of Internal Medicine, Section of Cardiovascular Medicine, Cardiovascular Research Center, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America, Raymond and Beverly Sackler Foundation Cardiovascular Laboratory, New Haven, Connecticut, United States of America
⨯
Timur O. Yarovinsky,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Supervision

Affiliations Department of Internal Medicine, Section of Cardiovascular Medicine, Cardiovascular Research Center, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America, Raymond and Beverly Sackler Foundation Cardiovascular Laboratory, New Haven, Connecticut, United States of America
⨯
Vinod S. Ramgolam,

Roles Methodology, Supervision

Affiliations Department of Internal Medicine, Section of Cardiovascular Medicine, Cardiovascular Research Center, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America, Raymond and Beverly Sackler Foundation Cardiovascular Laboratory, New Haven, Connecticut, United States of America
⨯
Matthias Gaestel,

Roles Methodology

Affiliation Institute of Biochemistry, Medical School Hannover, Hannover, Germany
⨯
Ruggero Pardi,

Roles Methodology, Supervision, Writing – review & editing

Affiliation Faculty of Medicine and Surgery, Università Vita-Salute San Raffaele, Milan, Italy
⨯
Jeffrey R. Bender

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Writing – original draft, Writing – review & editing

* E-mail: jeffrey.bender@yale.edu

Affiliations Department of Internal Medicine, Section of Cardiovascular Medicine, Cardiovascular Research Center, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America, Raymond and Beverly Sackler Foundation Cardiovascular Laboratory, New Haven, Connecticut, United States of America

http://orcid.org/0000-0003-3827-3672

⨯

T cell LFA-1-induced proinflammatory mRNA stabilization is mediated by the p38 pathway kinase MK2 in a process regulated by hnRNPs C, H1 and K

Gautham K. Rao,
Albert Wong,
Mark Collinge,
Joseph Sarhan,
Timur O. Yarovinsky,
Vinod S. Ramgolam,
Matthias Gaestel,
Ruggero Pardi,
Jeffrey R. Bender

Published: July 26, 2018
https://doi.org/10.1371/journal.pone.0201103

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.
Messenger RNA
Is the Subject Area "Messenger RNA" applicable to this article?

Thanks for your feedback.
Immunoprecipitation
Is the Subject Area "Immunoprecipitation" applicable to this article?

Thanks for your feedback.
Small interfering RNA
Is the Subject Area "Small interfering RNA" applicable to this article?

Thanks for your feedback.
Cytokines
Is the Subject Area "Cytokines" applicable to this article?

Thanks for your feedback.
Integrins
Is the Subject Area "Integrins" applicable to this article?

Thanks for your feedback.
RNA isolation
Is the Subject Area "RNA isolation" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.