Noninvasive assessment of dofetilide plasma concentration using a deep learning (neural network) analysis of the surface electrocardiogram: A proof of concept study

Zachi I. Attia; Alan Sugrue; Samuel J. Asirvatham; Michael J. Ackerman; Suraj Kapa; Paul A. Friedman; Peter A. Noseworthy

doi:10.1371/journal.pone.0201059

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Peer-reviewed

Research Article

Noninvasive assessment of dofetilide plasma concentration using a deep learning (neural network) analysis of the surface electrocardiogram: A proof of concept study

Zachi I. Attia ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

¶‡ These authors are co-first authors on this work.

Affiliation Division of Heart Rhythm Services, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Alan Sugrue ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

¶‡ These authors are co-first authors on this work.

Affiliation Division of Heart Rhythm Services, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America

http://orcid.org/0000-0001-9921-6968

⨯
Samuel J. Asirvatham,

Roles Conceptualization, Data curation, Investigation, Supervision, Writing – review & editing

Affiliations Division of Heart Rhythm Services, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America, Division of Pediatric Cardiology, Department of Pediatrics and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Michael J. Ackerman,

Roles Conceptualization, Data curation, Investigation, Supervision, Writing – review & editing

Affiliations Division of Pediatric Cardiology, Department of Pediatrics and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, United States of America, Windland Smith Rice Sudden Death Genomics Laboratory, Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Suraj Kapa,

Roles Conceptualization, Data curation, Investigation, Methodology, Supervision, Writing – review & editing

Affiliation Division of Heart Rhythm Services, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Paul A. Friedman,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – review & editing

Affiliation Division of Heart Rhythm Services, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Peter A. Noseworthy

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Supervision, Writing – original draft, Writing – review & editing

* E-mail: noseworthy.peter@mayo.edu

Affiliation Division of Heart Rhythm Services, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America
⨯

Noninvasive assessment of dofetilide plasma concentration using a deep learning (neural network) analysis of the surface electrocardiogram: A proof of concept study

Zachi I. Attia,
Alan Sugrue,
Samuel J. Asirvatham,
Michael J. Ackerman,
Suraj Kapa,
Paul A. Friedman,
Peter A. Noseworthy

Published: August 22, 2018
https://doi.org/10.1371/journal.pone.0201059

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Blood plasma
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Atrial fibrillation
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