Germline single nucleotide polymorphisms in ERBB3 and BARD1 genes result in a worse relapse free survival response for HER2-positive breast cancer patients treated with adjuvant based docetaxel, carboplatin and trastuzumab (TCH)

• Damien Coté ,

  Contributed equally to this work with: Damien Coté, Alex Eustace

  Roles Formal analysis, Validation, Writing – original draft, Writing – review & editing

  * E-mail: DamienCote@rcsi.ie

  Affiliation Royal College of Surgeons in Ireland, Data Science Centre, Dublin, Ireland

  http://orcid.org/0000-0002-4011-8965

  ⨯
• Alex Eustace ,

  Contributed equally to this work with: Damien Coté, Alex Eustace

  Roles Supervision, Writing – original draft, Writing – review & editing

  Affiliation Dublin City University, National Institute for Cellular Biotechnology, Molecular Therapeutics for Cancer in Ireland, Dublin, Ireland

  ⨯
• Sinead Toomey,

  Roles Methodology, Writing – review & editing

  Affiliation Royal College of Surgeons in Ireland, Department of Molecular Medicine, Medical Oncology Group, Dublin, Ireland

  ⨯
• Mattia Cremona,

  Roles Methodology, Writing – review & editing

  Affiliation Royal College of Surgeons in Ireland, Department of Molecular Medicine, Medical Oncology Group, Dublin, Ireland

  ⨯
• Malgorzata Milewska,

  Roles Methodology, Writing – review & editing

  Affiliation Royal College of Surgeons in Ireland, Department of Molecular Medicine, Medical Oncology Group, Dublin, Ireland

  ⨯
• Simon Furney,

  Roles Methodology, Writing – review & editing

  Affiliation Royal College of Surgeons in Ireland, Department of Physiology and Medical Physics, Dublin, Ireland

  ⨯
• Aoife Carr,

  Roles Methodology, Writing – review & editing

  Affiliation Royal College of Surgeons in Ireland, Department of Molecular Medicine, Medical Oncology Group, Dublin, Ireland

  ⨯
• Joanna Fay,

  Roles Methodology, Writing – review & editing

  Affiliation Royal College of Surgeons in Ireland, Department of Pathology, Dublin, Ireland

  ⨯
• Elaine Kay,

  Roles Methodology, Writing – review & editing

  Affiliation Royal College of Surgeons in Ireland, Department of Pathology, Dublin, Ireland

  ⨯
• Susan Kennedy,

  Roles Investigation, Writing – review & editing

  Affiliation St Vincent’s University Hospital, Medical Oncology, Dublin, Ireland

  ⨯
• John Crown,

  Roles Investigation, Writing – review & editing

  Affiliations Dublin City University, National Institute for Cellular Biotechnology, Molecular Therapeutics for Cancer in Ireland, Dublin, Ireland, St Vincent’s University Hospital, Medical Oncology, Dublin, Ireland

  ⨯
• Bryan Hennessy ,

  Roles Investigation, Supervision, Writing – review & editing

  ¶‡ These authors also contributed equally to this work.

  Affiliations Royal College of Surgeons in Ireland, Department of Molecular Medicine, Medical Oncology Group, Dublin, Ireland, Beaumont Hospital, Department of Medical Oncology, Dublin, Ireland

  ⨯
• Stephen Madden

  Roles Supervision, Writing – review & editing

  ¶‡ These authors also contributed equally to this work.

  Affiliation Royal College of Surgeons in Ireland, Data Science Centre, Dublin, Ireland

  ⨯