PNPase knockout results in mtDNA loss and an altered metabolic gene expression program

• Eriko Shimada ,

  Contributed equally to this work with: Eriko Shimada, Fasih M. Ahsan

  Roles Conceptualization, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Molecular Biology Institute Interdepartmental Program, University of California Los Angeles, Los Angeles, California, United States of America

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• Fasih M. Ahsan ,

  Contributed equally to this work with: Eriko Shimada, Fasih M. Ahsan

  Roles Investigation, Methodology, Writing – original draft

  Affiliation Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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• Mahta Nili,

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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• Dian Huang,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Bioengineering, University of California Los Angeles, Los Angeles, California, United States of America

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• Sean Atamdede,

  Roles Investigation

  Affiliation Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, California, United States of America

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• Tara TeSlaa,

  Roles Investigation, Writing – review & editing

  Affiliation Molecular Biology Institute Interdepartmental Program, University of California Los Angeles, Los Angeles, California, United States of America

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• Dana Case,

  Roles Investigation, Writing – review & editing

  Affiliation Molecular Biology Institute Interdepartmental Program, University of California Los Angeles, Los Angeles, California, United States of America

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• Xiang Yu,

  Roles Writing – review & editing

  Affiliation Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Brian D. Gregory,

  Roles Conceptualization

  Affiliation Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Benjamin J. Perrin,

  Roles Investigation, Resources

  Affiliation Department of Biology, Indiana University–Purdue University Indianapolis, Indianapolis, Indiana, United States of America

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• Carla M. Koehler ,

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

  * E-mail: koehlerc@chem.ucla.edu (CMK); mteitell@mednet.ucla.edu (MAT)

  Affiliations Molecular Biology Institute Interdepartmental Program, University of California Los Angeles, Los Angeles, California, United States of America, Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, California, United States of America, Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, United States of America

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• Michael A. Teitell

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

  * E-mail: koehlerc@chem.ucla.edu (CMK); mteitell@mednet.ucla.edu (MAT)

  Affiliations Molecular Biology Institute Interdepartmental Program, University of California Los Angeles, Los Angeles, California, United States of America, Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California, United States of America, Department of Bioengineering, University of California Los Angeles, Los Angeles, California, United States of America, Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, United States of America, Broad Center for Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, California, United States of America, Department of Pediatrics, University of California Los Angeles, Los Angeles, California, United States of America, California NanoSystems Institute, University of California Los Angeles, Los Angeles, California, United States of America

  http://orcid.org/0000-0002-4495-8750

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