miR-122 inhibition in a human liver organoid model leads to liver inflammation, necrosis, steatofibrosis and dysregulated insulin signaling

• Hossein Sendi ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: hsendi@email.unc.edu

  Current address: Center for Nanotechnology in Drug Delivery, UNC School of Pharmacy, Chapel Hill, NC, United States of America

  Affiliations The Laboratory for Liver Diseases and Metabolic Disorders, Section on Gastroenterology, Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC, United States of America, Wake Forest Institute of Regenerative Medicine, Winston-Salem, NC, United States of America

  http://orcid.org/0000-0002-1054-6571

  ⨯
• Ivy Mead,

  Roles Investigation, Methodology

  Affiliation Wake Forest Institute of Regenerative Medicine, Winston-Salem, NC, United States of America

  ⨯
• Meimei Wan,

  Roles Investigation, Methodology

  Affiliation Wake Forest Institute of Regenerative Medicine, Winston-Salem, NC, United States of America

  ⨯
• Marjan Mehrab-Mohseni,

  Roles Software, Writing – original draft, Writing – review & editing

  Current address: Center for Integrative Chemical Biology and Drug Discovery, UNC School of Pharmacy, Chapel Hill, NC, Current address

  Affiliation The Laboratory for Liver Diseases and Metabolic Disorders, Section on Gastroenterology, Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC, United States of America

  ⨯
• Kenneth Koch,

  Roles Funding acquisition, Resources

  Affiliation The Laboratory for Liver Diseases and Metabolic Disorders, Section on Gastroenterology, Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC, United States of America

  ⨯
• Anthony Atala,

  Roles Funding acquisition, Resources

  Affiliation Wake Forest Institute of Regenerative Medicine, Winston-Salem, NC, United States of America

  ⨯
• Herbert L. Bonkovsky,

  Roles Funding acquisition, Resources, Supervision

  Affiliation The Laboratory for Liver Diseases and Metabolic Disorders, Section on Gastroenterology, Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC, United States of America

  ⨯
• Colin E. Bishop

  Roles Funding acquisition, Resources, Supervision

  Affiliation Wake Forest Institute of Regenerative Medicine, Winston-Salem, NC, United States of America

  ⨯