Amino acid deprivation triggers a novel GCN2-independent response leading to the transcriptional reactivation of non-native DNA sequences

Annarosaria De Vito; Massimo Lazzaro; Ilaria Palmisano; Davide Cittaro; Michela Riba; Dejan Lazarevic; Makoto Bannai; Davide Gabellini; Maria Vittoria Schiaffino

doi:10.1371/journal.pone.0200783

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Open Access

Peer-reviewed

Research Article

Amino acid deprivation triggers a novel GCN2-independent response leading to the transcriptional reactivation of non-native DNA sequences

Annarosaria De Vito,

Roles Formal analysis, Investigation

Affiliation Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy
⨯
Massimo Lazzaro,

Roles Formal analysis, Investigation

Affiliation Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy
⨯
Ilaria Palmisano,

Roles Formal analysis, Investigation

Current address: Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom.

Affiliation Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy
⨯
Davide Cittaro,

Roles Formal analysis

Affiliation Center for Translational Genomics and Bioinformatics, IRCCS San Raffaele Scientific Institute, Milan, Italy

http://orcid.org/0000-0003-0384-3700

⨯
Michela Riba,

Roles Formal analysis

Affiliation Center for Translational Genomics and Bioinformatics, IRCCS San Raffaele Scientific Institute, Milan, Italy
⨯
Dejan Lazarevic,

Roles Investigation

Affiliation Center for Translational Genomics and Bioinformatics, IRCCS San Raffaele Scientific Institute, Milan, Italy

http://orcid.org/0000-0001-7485-4189

⨯
Makoto Bannai,

Roles Conceptualization, Resources

Affiliation Frontier Research Labs, Institute for Innovation, Ajinomoto Co., Kawasaki, Tokyo, Japan
⨯
Davide Gabellini,

Roles Conceptualization, Funding acquisition, Writing – review & editing

Affiliation Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy
⨯
Maria Vittoria Schiaffino

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: schiaffino.mariavittoria@hsr.it

Affiliation Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy

http://orcid.org/0000-0001-9744-7025

⨯

Amino acid deprivation triggers a novel GCN2-independent response leading to the transcriptional reactivation of non-native DNA sequences

Annarosaria De Vito,
Massimo Lazzaro,
Ilaria Palmisano,
Davide Cittaro,
Michela Riba,
Dejan Lazarevic,
Makoto Bannai,
Davide Gabellini,
Maria Vittoria Schiaffino

Published: July 18, 2018
https://doi.org/10.1371/journal.pone.0200783

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