Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175+/- mouse model of Huntington’s Disease

Joseph W. Goodliffe; Hanbing Song; Anastasia Rubakovic; Wayne Chang; Maria Medalla; Christina M. Weaver; Jennifer I. Luebke

doi:10.1371/journal.pone.0200626

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Peer-reviewed

Research Article

Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175^+/- mouse model of Huntington’s Disease

Joseph W. Goodliffe,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Anatomy & Neurobiology, Boston University School of Medicine, Boston, Massachusetts
⨯
Hanbing Song,

Roles Data curation, Investigation

Affiliation Department of Mathematics and Computer Science, Franklin & Marshall College, Lancaster, Pennsylvania
⨯
Anastasia Rubakovic,

Roles Data curation, Investigation

Affiliation Department of Anatomy & Neurobiology, Boston University School of Medicine, Boston, Massachusetts
⨯
Wayne Chang,

Roles Data curation, Investigation, Writing – review & editing

Affiliation Department of Anatomy & Neurobiology, Boston University School of Medicine, Boston, Massachusetts
⨯
Maria Medalla,

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Anatomy & Neurobiology, Boston University School of Medicine, Boston, Massachusetts
⨯
Christina M. Weaver ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Writing – original draft, Writing – review & editing

¶‡ These authors are co-senior authors on this work.

Affiliation Department of Mathematics and Computer Science, Franklin & Marshall College, Lancaster, Pennsylvania
⨯
Jennifer I. Luebke

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: jluebke@bu.edu

¶‡ These authors are co-senior authors on this work.

Affiliation Department of Anatomy & Neurobiology, Boston University School of Medicine, Boston, Massachusetts

http://orcid.org/0000-0003-1399-6073

⨯

Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175^+/- mouse model of Huntington’s Disease

Joseph W. Goodliffe,
Hanbing Song,
Anastasia Rubakovic,
Wayne Chang,
Maria Medalla,
Christina M. Weaver,
Jennifer I. Luebke

Published: August 17, 2018
https://doi.org/10.1371/journal.pone.0200626

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Mouse models
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Huntington disease
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