In vitro cytotoxicity of superheated steam hydrolyzed oligo((R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate) and characteristics of its blend with poly(L-lactic acid) for biomaterial applications

Dhurga Devi Rajaratanam; Hidayah Ariffin; Mohd Ali Hassan; Nik Mohd Afizan Nik Abd Rahman; Haruo Nishida

doi:10.1371/journal.pone.0199742

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Open Access

Peer-reviewed

Research Article

In vitro cytotoxicity of superheated steam hydrolyzed oligo((R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate) and characteristics of its blend with poly(L-lactic acid) for biomaterial applications

Dhurga Devi Rajaratanam,

Roles Data curation, Formal analysis, Writing – original draft

Affiliations Department of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, UPM Serdang, Malaysia, Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Hibikino, Wakamatsu, Kitakyushu, Fukuoka, Japan
⨯
Hidayah Ariffin ,

Roles Conceptualization, Data curation, Supervision, Validation, Writing – review & editing

* E-mail: hidayah@upm.edu.my

Affiliations Department of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, UPM Serdang, Malaysia, Institute of Tropical Forestry and Forest Products (INTROP), Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia

http://orcid.org/0000-0002-9381-6767

⨯
Mohd Ali Hassan,

Roles Supervision, Validation

Affiliation Department of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, UPM Serdang, Malaysia
⨯
Nik Mohd Afizan Nik Abd Rahman,

Roles Conceptualization, Formal analysis, Methodology, Resources

Affiliation Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, UPM Serdang, Malaysia
⨯
Haruo Nishida

Roles Supervision, Writing – review & editing

Affiliation Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Hibikino, Wakamatsu, Kitakyushu, Fukuoka, Japan
⨯

In vitro cytotoxicity of superheated steam hydrolyzed oligo((R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate) and characteristics of its blend with poly(L-lactic acid) for biomaterial applications

Dhurga Devi Rajaratanam,
Hidayah Ariffin,
Mohd Ali Hassan,
Nik Mohd Afizan Nik Abd Rahman,
Haruo Nishida

Published: June 26, 2018
https://doi.org/10.1371/journal.pone.0199742

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