High-fat diet suppresses the positive effect of creatine supplementation on skeletal muscle function by reducing protein expression of IGF-PI3K-AKT-mTOR pathway

• Renato Ferretti ,

  Contributed equally to this work with: Renato Ferretti, Matias Mosqueira

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: r.ferretti@unesp.br (RF); matias@physiologie.uni-heidelberg.de (MM)

  Affiliation Department of Anatomy, Institute of Bioscience of Botucatu, São Paulo State University—UNESP, Botucatu, São Paulo, Brazil

  http://orcid.org/0000-0003-3944-1906

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• Eliezer Guimarães Moura ,

  Roles Formal analysis, Investigation, Methodology

  ¶‡ These authors also contributed equally to this work.

  Affiliation Laboratory of Physical Activity, Metabolism and Health, Centro Universitario Adventista de Sao Paulo, Hortolandia, São Paulo, Brazil

  http://orcid.org/0000-0002-2477-8242

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• Veridiana Carvalho dos Santos ,

  Roles Formal analysis, Investigation, Methodology

  ¶‡ These authors also contributed equally to this work.

  Affiliation Department of Anatomy, Institute of Bioscience of Botucatu, São Paulo State University—UNESP, Botucatu, São Paulo, Brazil

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• Eduardo José Caldeira,

  Roles Conceptualization, Supervision

  Affiliation Department of Morphology and Basic Pathology, Faculty of Medicine of Jundiai—FMJ, Jundiai, São Paulo, Brazil

  ⨯
• Marcelo Conte,

  Roles Conceptualization, Supervision

  Affiliation Escola Superior de Educação Física—ESEF, Jundiai, São Paulo, Brazil

  ⨯
• Cintia Yuri Matsumura,

  Roles Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Anatomy, Institute of Bioscience of Botucatu, São Paulo State University—UNESP, Botucatu, São Paulo, Brazil

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• Adriana Pertille,

  Roles Formal analysis, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Laboratory of Neuromuscular Plasticity, Graduate Program in Science of Human Movement, Universidade Metodista de Piracicaba, Piracicaba, São Paulo, Brazil

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• Matias Mosqueira

  Contributed equally to this work with: Renato Ferretti, Matias Mosqueira

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: r.ferretti@unesp.br (RF); matias@physiologie.uni-heidelberg.de (MM)

  Affiliation Cardio-Ventilatory Muscle Physiology Laboratory, Institute of Physiology and Pathophysiology, Heidelberg University Hospital, Heidelberg, Germany

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