ARQ-197, a small-molecule inhibitor of c-Met, reduces tumour burden and prevents myeloma-induced bone disease in vivo

• Darren L. Lath ,

  Contributed equally to this work with: Darren L. Lath, Clive H. Buckle

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing – original draft

  * E-mail: d.lath@shef.ac.uk

  Affiliations Department of Oncology and Metabolism, Medical School, University of Sheffield, Sheffield, United Kingdom, Mellanby Centre for Bone Research, Medical School, University of Sheffield, Sheffield, United Kingdom

  http://orcid.org/0000-0001-5454-9419

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• Clive H. Buckle ,

  Contributed equally to this work with: Darren L. Lath, Clive H. Buckle

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  Affiliations Department of Oncology and Metabolism, Medical School, University of Sheffield, Sheffield, United Kingdom, Mellanby Centre for Bone Research, Medical School, University of Sheffield, Sheffield, United Kingdom

  ⨯
• Holly R. Evans,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliations Department of Oncology and Metabolism, Medical School, University of Sheffield, Sheffield, United Kingdom, Mellanby Centre for Bone Research, Medical School, University of Sheffield, Sheffield, United Kingdom

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• Matthew Fisher,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Oncology and Metabolism, Medical School, University of Sheffield, Sheffield, United Kingdom

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• Jenny M. Down,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations Department of Oncology and Metabolism, Medical School, University of Sheffield, Sheffield, United Kingdom, Mellanby Centre for Bone Research, Medical School, University of Sheffield, Sheffield, United Kingdom

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• Michelle A. Lawson ,

  Roles Conceptualization, Investigation, Methodology, Supervision, Writing – review & editing

  ¶‡ These authors also contributed equally to this work.

  Affiliations Department of Oncology and Metabolism, Medical School, University of Sheffield, Sheffield, United Kingdom, Mellanby Centre for Bone Research, Medical School, University of Sheffield, Sheffield, United Kingdom

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• Andrew D. Chantry

  Roles Conceptualization, Resources, Supervision, Writing – review & editing

  ¶‡ These authors also contributed equally to this work.

  Affiliations Department of Oncology and Metabolism, Medical School, University of Sheffield, Sheffield, United Kingdom, Mellanby Centre for Bone Research, Medical School, University of Sheffield, Sheffield, United Kingdom, Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield, United Kingdom

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