Coding variants in NOD-like receptors: An association study on risk and survival of colorectal cancer

Stefanie Huhn; Miguel I. da Silva Filho; Tharmila Sanmuganantham; Tica Pichulik; Calogerina Catalano; Barbara Pardini; Alessio Naccarati; Veronika Polakova-Vymetálkova; Katerina Jiraskova; Ludmila Vodickova; Pavel Vodicka; Markus W. Löffler; Lioba Courth; Jan Wehkamp; Farhat V. N. Din; Maria Timofeeva; Susan M. Farrington; Lina Jansen; Kari Hemminki; Jenny Chang-Claude; Hermann Brenner; Michael Hoffmeister; Malcolm G. Dunlop; Alexander N. R. Weber; Asta Försti

doi:10.1371/journal.pone.0199350

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Open Access

Peer-reviewed

Research Article

Coding variants in NOD-like receptors: An association study on risk and survival of colorectal cancer

Stefanie Huhn ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Visualization, Writing – original draft, Writing – review & editing

* E-mail: Stefanie.Huhn@med.uni-heidelberg.de (SH); alexander.weber@uni.tuebingen.de (AW)

Affiliations Department of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Multiple Myeloma, Internal Medicine V: Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany

http://orcid.org/0000-0003-1700-2371

⨯
Miguel I. da Silva Filho,

Roles Formal analysis, Visualization, Writing – review & editing

Affiliation Department of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Tharmila Sanmuganantham,

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliation Interfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Tübingen, Germany
⨯
Tica Pichulik,

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliation Interfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Tübingen, Germany
⨯
Calogerina Catalano,

Roles Data curation, Investigation, Writing – review & editing

Affiliation Department of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Barbara Pardini,

Roles Data curation, Writing – review & editing

Affiliations Italian Institute for Genomic Medicine (IIGM), Turin, Italy, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
⨯
Alessio Naccarati,

Roles Data curation, Writing – review & editing

Affiliations Italian Institute for Genomic Medicine (IIGM), Turin, Italy, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
⨯
Veronika Polakova-Vymetálkova,

Roles Data curation, Writing – review & editing

Affiliations Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic, Institute of Biology and Medical Genetics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
⨯
Katerina Jiraskova,

Roles Data curation, Writing – review & editing

Affiliations Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic, Institute of Biology and Medical Genetics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic

http://orcid.org/0000-0001-8462-6358

⨯
Ludmila Vodickova,

Roles Data curation, Supervision, Writing – review & editing

Affiliations Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic, Institute of Biology and Medical Genetics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Biomedical Centre, Faculty of Medicine Pilsen, Charles University Prague, Pilsen, Czech Republic
⨯
Pavel Vodicka,

Roles Data curation, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

Affiliations Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic, Institute of Biology and Medical Genetics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Biomedical Centre, Faculty of Medicine Pilsen, Charles University Prague, Pilsen, Czech Republic
⨯
Markus W. Löffler,

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliations Interfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Tübingen, Germany, Department of General, Visceral and Transplant Surgery, University Hospital Tübingen, Tübingen, Germany
⨯
Lioba Courth,

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliation Department of Internal Medicine I, University Hospital Tübingen, Tübingen, Germany
⨯
Jan Wehkamp,

Roles Funding acquisition, Project administration, Resources, Writing – review & editing

Affiliation Department of Internal Medicine I, University Hospital Tübingen, Tübingen, Germany
⨯
Farhat V. N. Din,

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliation Colon Cancer Genetics Group, MRC Human Genetics Unit, The University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
⨯
Maria Timofeeva,

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliation Colon Cancer Genetics Group, MRC Human Genetics Unit, The University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
⨯
Susan M. Farrington,

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliation Colon Cancer Genetics Group, MRC Human Genetics Unit, The University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom

http://orcid.org/0000-0001-5955-7389

⨯
Lina Jansen,

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliation Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Kari Hemminki,

Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

Affiliations Department of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, SE, Sweden
⨯
Jenny Chang-Claude,

Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

Affiliation Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Hermann Brenner,

Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

Affiliations Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany, Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, Heidelberg, Germany, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Michael Hoffmeister,

Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

Affiliation Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Malcolm G. Dunlop,

Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

Affiliation Colon Cancer Genetics Group, MRC Human Genetics Unit, The University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
⨯
Alexander N. R. Weber ,

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: Stefanie.Huhn@med.uni-heidelberg.de (SH); alexander.weber@uni.tuebingen.de (AW)

Affiliation Interfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Tübingen, Germany
⨯
[ ... ],
Asta Försti

Roles Conceptualization, Project administration, Resources, Supervision, Writing – review & editing

Affiliations Department of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, SE, Sweden
⨯
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Coding variants in NOD-like receptors: An association study on risk and survival of colorectal cancer

Stefanie Huhn,
Miguel I. da Silva Filho,
Tharmila Sanmuganantham,
Tica Pichulik,
Calogerina Catalano,
Barbara Pardini,
Alessio Naccarati,
Veronika Polakova-Vymetálkova,
Katerina Jiraskova,
Ludmila Vodickova

Published: June 21, 2018
https://doi.org/10.1371/journal.pone.0199350

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Colorectal cancer
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Single nucleotide polymorphisms
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Cancer risk factors
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Gene expression
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Variant genotypes
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Genome-wide association studies
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Colon
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Immune cells
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