The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation

Yann Thomas; Daniel C. Scott; Yosua Adi Kristariyanto; Jesse Rinehart; Kristopher Clark; Philip Cohen; Thimo Kurz

doi:10.1371/journal.pone.0199197

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Peer-reviewed

Research Article

The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation

Yann Thomas,

Roles Investigation, Writing – original draft, Writing – review & editing

Current address: Institut Jacques Monod, UMR7592, Paris-Diderot Université, Centre National de la Recherche Scientifique, Paris, France

Affiliation Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯
Daniel C. Scott,

Roles Investigation

Affiliation Department of Structural Biology, Howard Hughes Medical Institute, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Yosua Adi Kristariyanto,

Roles Investigation

Affiliation Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯
Jesse Rinehart,

Roles Resources

Affiliations Department of Cellular & Molecular Physiology, Yale University, New Haven, Connecticut, United States of America, Systems Biology Institute, Yale University, West Haven, Connecticut, United States of America
⨯
Kristopher Clark,

Roles Investigation

Affiliation Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯
Philip Cohen,

Roles Resources

Affiliation Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, United Kingdom
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Thimo Kurz

Roles Supervision, Writing – original draft, Writing – review & editing

* E-mail: thimo.kurz@glasgow.ac.uk

Current address: Institute of Molecular, Cell and Systems Biology, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

Affiliation Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, United Kingdom

http://orcid.org/0000-0003-0700-6993

⨯

The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation

Yann Thomas,
Daniel C. Scott,
Yosua Adi Kristariyanto,
Jesse Rinehart,
Kristopher Clark,
Philip Cohen,
Thimo Kurz

Published: June 29, 2018
https://doi.org/10.1371/journal.pone.0199197

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Phosphorylation
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Immunoprecipitation
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Macrophages
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Small interfering RNA
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Serine
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Cell signaling
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Immunoblotting
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Immune receptor signaling
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