Low-dose ionizing radiation exposure represses the cell cycle and protein synthesis pathways in in vitro human primary keratinocytes and U937 cell lines

Kazumasa Sekihara; Kaori Saitoh; Haeun Yang; Haruki Kawashima; Saiko Kazuno; Mika Kikkawa; Hajime Arai; Takashi Miida; Nobuhiro Hayashi; Keisuke Sasai; Yoko Tabe

doi:10.1371/journal.pone.0199117

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Open Access

Peer-reviewed

Research Article

Low-dose ionizing radiation exposure represses the cell cycle and protein synthesis pathways in in vitro human primary keratinocytes and U937 cell lines

Kazumasa Sekihara,

Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Writing – original draft, Writing – review & editing

Current address: Department of Molecular Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

Affiliations Department of Laboratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan, Leading Center for the Development and Research of Cancer Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
⨯
Kaori Saitoh,

Roles Data curation, Investigation

Affiliation Department of Laboratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
⨯
Haeun Yang,

Roles Data curation, Investigation

Affiliations Department of Laboratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan, Leading Center for the Development and Research of Cancer Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
⨯
Haruki Kawashima,

Roles Data curation, Investigation

Affiliation Deparmentof Life Science and Technology, Tokyo Institute of Technology Graduate School of Bioscience and Biotechnology, Tokyo, Japan
⨯
Saiko Kazuno,

Roles Data curation, Investigation

Affiliation Laboratory of Proteomics and Biomolecular Science, Research Support Center, Juntendo University Graduate School of Medicine, Tokyo, Japan
⨯
Mika Kikkawa,

Roles Data curation, Investigation

Affiliation Laboratory of Proteomics and Biomolecular Science, Research Support Center, Juntendo University Graduate School of Medicine, Tokyo, Japan
⨯
Hajime Arai,

Roles Data curation, Investigation

Affiliation Laboratory of Proteomics and Biomolecular Science, Research Support Center, Juntendo University Graduate School of Medicine, Tokyo, Japan
⨯
Takashi Miida,

Roles Project administration, Resources

Affiliation Department of Laboratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
⨯
Nobuhiro Hayashi,

Roles Conceptualization

Affiliation Deparmentof Life Science and Technology, Tokyo Institute of Technology Graduate School of Bioscience and Biotechnology, Tokyo, Japan
⨯
Keisuke Sasai,

Roles Conceptualization

Affiliation Department of Radiation Oncology, Juntendo University Graduate School of Medicine, Tokyo, Japan
⨯
Yoko Tabe

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Supervision, Writing – original draft, Writing – review & editing

* E-mail: tabe@juntendo.ac.jp

Affiliations Department of Laboratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan, Department of Next Generation Hematology Laboratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
⨯

Low-dose ionizing radiation exposure represses the cell cycle and protein synthesis pathways in in vitro human primary keratinocytes and U937 cell lines

Kazumasa Sekihara,
Kaori Saitoh,
Haeun Yang,
Haruki Kawashima,
Saiko Kazuno,
Mika Kikkawa,
Hajime Arai,
Takashi Miida,
Nobuhiro Hayashi,
Keisuke Sasai

Published: June 18, 2018
https://doi.org/10.1371/journal.pone.0199117

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Cytokines
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Protein expression
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Inflammation
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Cell growth
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Gene expression
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Keratinocytes
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MAPK signaling cascades
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Protein synthesis
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