The route of administration influences the therapeutic index of an anti-proNGF neutralizing mAb for experimental treatment of Diabetic Retinopathy

• Pablo F. Barcelona ,

  Contributed equally to this work with: Pablo F. Barcelona, Alba Galan

  Roles Data curation, Formal analysis, Investigation, Validation, Writing – original draft, Writing – review & editing

  Affiliations Lady Davis Institute-Jewish General Hospital; Center for Translational Research, McGill University, Montreal, Quebec, Canada, Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada

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• Alba Galan ,

  Contributed equally to this work with: Pablo F. Barcelona, Alba Galan

  Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Lady Davis Institute-Jewish General Hospital; Center for Translational Research, McGill University, Montreal, Quebec, Canada

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• Hinyu Nedev,

  Roles Formal analysis, Investigation

  Affiliation Lady Davis Institute-Jewish General Hospital; Center for Translational Research, McGill University, Montreal, Quebec, Canada

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• Yifan Jian,

  Roles Methodology, Software

  Affiliation School of Engineering Science, Simon Fraser University, BC, Canada

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• Marinko V. Sarunic,

  Roles Funding acquisition, Software

  Affiliation School of Engineering Science, Simon Fraser University, BC, Canada

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• H. Uri Saragovi

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: uri.saragovi@mcgill.ca

  Affiliations Lady Davis Institute-Jewish General Hospital; Center for Translational Research, McGill University, Montreal, Quebec, Canada, Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada, Department of Ophthalmology and Integrated Program for Neuroscience, McGill University, Montreal, Quebec, Canada

  http://orcid.org/0000-0001-6884-8815

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