Structural and functional studies of histidine biosynthesis in Acanthamoeba spp. demonstrates a novel molecular arrangement and target for antimicrobials

• Christopher A. Rice,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Current address: Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America

  Affiliations Institute of Biomedical and Environmental Health Research, School of Science and Sport, University of West of Scotland, Paisley, United Kingdom, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom

  http://orcid.org/0000-0003-0672-9604

  ⨯
• Sara J. Campbell,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Institute of Biomedical and Environmental Health Research, School of Science and Sport, University of West of Scotland, Paisley, United Kingdom

  ⨯
• Claudine Bisson,

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Writing – original draft, Writing – review & editing

  Current address: Department of Biological Sciences, Birkbeck College, University of London, London, United Kingdom

  Affiliation Department of Molecular Biology and Biotechnology, Krebs Institute for Biomolecular Research, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom

  ⨯
• Hayley J. Owen,

  Roles Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Molecular Biology and Biotechnology, Krebs Institute for Biomolecular Research, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom

  ⨯
• Svetlana E. Sedelnikova,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Molecular Biology and Biotechnology, Krebs Institute for Biomolecular Research, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom

  ⨯
• Patrick J. Baker,

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Molecular Biology and Biotechnology, Krebs Institute for Biomolecular Research, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom

  ⨯
• David W. Rice,

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Software, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Molecular Biology and Biotechnology, Krebs Institute for Biomolecular Research, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom

  ⨯
• Fiona L. Henriquez ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: fiona.henriquez@uws.ac.uk (F.L.H.); c.w.roberts@strath.ac.uk (C.W.R.)

  Affiliation Institute of Biomedical and Environmental Health Research, School of Science and Sport, University of West of Scotland, Paisley, United Kingdom

  ⨯
• Craig W. Roberts

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: fiona.henriquez@uws.ac.uk (F.L.H.); c.w.roberts@strath.ac.uk (C.W.R.)

  Affiliation Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom

  ⨯