Bone substitute made from a Brazilian oyster shell functions as a fast stimulator for bone-forming cells in an animal model

Ricardo Coringa; Eduardo Martins de Sousa; Juliana Nunes Botelho; Rafael Soares Diniz; Joicy Cortez de Sá; Maria Carmen Fontoura Nogueira da Cruz; Marco Aurelio Beninni Paschoal; Letícia Machado Gonçalves

doi:10.1371/journal.pone.0198697

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Research Article

Bone substitute made from a Brazilian oyster shell functions as a fast stimulator for bone-forming cells in an animal model

Ricardo Coringa ,

Contributed equally to this work with: Ricardo Coringa, Eduardo Martins de Sousa, Juliana Nunes Botelho, Rafael Soares Diniz, Joicy Cortez de Sá, Maria Carmen Fontoura Nogueira da Cruz, Marco Aurelio Beninni Paschoal, Letícia Machado Gonçalves

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology

Affiliation Department of Dentistry, CEUMA University, Sao Luis, Maranhao, Brazil
⨯
Eduardo Martins de Sousa ,

Contributed equally to this work with: Ricardo Coringa, Eduardo Martins de Sousa, Juliana Nunes Botelho, Rafael Soares Diniz, Joicy Cortez de Sá, Maria Carmen Fontoura Nogueira da Cruz, Marco Aurelio Beninni Paschoal, Letícia Machado Gonçalves

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology

Affiliation Department of Immunology and Microbiology of Respiratory Tract Infections, Post-Graduate Program in Parasite Biology, CEUMA University, Sao Luis, Maranhao, Brazil
⨯
Juliana Nunes Botelho ,

Contributed equally to this work with: Ricardo Coringa, Eduardo Martins de Sousa, Juliana Nunes Botelho, Rafael Soares Diniz, Joicy Cortez de Sá, Maria Carmen Fontoura Nogueira da Cruz, Marco Aurelio Beninni Paschoal, Letícia Machado Gonçalves

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology

Affiliation Department of Oral Rehabilitation, University of Talca, Talca, Chile
⨯
Rafael Soares Diniz ,

Contributed equally to this work with: Ricardo Coringa, Eduardo Martins de Sousa, Juliana Nunes Botelho, Rafael Soares Diniz, Joicy Cortez de Sá, Maria Carmen Fontoura Nogueira da Cruz, Marco Aurelio Beninni Paschoal, Letícia Machado Gonçalves

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology

Affiliation Department of Dentistry, CEUMA University, Sao Luis, Maranhao, Brazil
⨯
Joicy Cortez de Sá ,

Contributed equally to this work with: Ricardo Coringa, Eduardo Martins de Sousa, Juliana Nunes Botelho, Rafael Soares Diniz, Joicy Cortez de Sá, Maria Carmen Fontoura Nogueira da Cruz, Marco Aurelio Beninni Paschoal, Letícia Machado Gonçalves

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology

Affiliation Department of Immunology and Microbiology of Respiratory Tract Infections, Post-Graduate Program in Parasite Biology, CEUMA University, Sao Luis, Maranhao, Brazil
⨯
Maria Carmen Fontoura Nogueira da Cruz ,

Contributed equally to this work with: Ricardo Coringa, Eduardo Martins de Sousa, Juliana Nunes Botelho, Rafael Soares Diniz, Joicy Cortez de Sá, Maria Carmen Fontoura Nogueira da Cruz, Marco Aurelio Beninni Paschoal, Letícia Machado Gonçalves

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology

Affiliation Department of Dentistry, Federal University of Maranhao, Sao Luis, Maranhao, Brazil
⨯
Marco Aurelio Beninni Paschoal ,

Contributed equally to this work with: Ricardo Coringa, Eduardo Martins de Sousa, Juliana Nunes Botelho, Rafael Soares Diniz, Joicy Cortez de Sá, Maria Carmen Fontoura Nogueira da Cruz, Marco Aurelio Beninni Paschoal, Letícia Machado Gonçalves

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology

Affiliation Department of Dentistry, CEUMA University, Sao Luis, Maranhao, Brazil
⨯
Letícia Machado Gonçalves

Contributed equally to this work with: Ricardo Coringa, Eduardo Martins de Sousa, Juliana Nunes Botelho, Rafael Soares Diniz, Joicy Cortez de Sá, Maria Carmen Fontoura Nogueira da Cruz, Marco Aurelio Beninni Paschoal, Letícia Machado Gonçalves

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology

* E-mail: lets.mg@gmail.com

Affiliation Department of Dentistry, CEUMA University, Sao Luis, Maranhao, Brazil

http://orcid.org/0000-0002-0096-0162

⨯

Bone substitute made from a Brazilian oyster shell functions as a fast stimulator for bone-forming cells in an animal model

Ricardo Coringa,
Eduardo Martins de Sousa,
Juliana Nunes Botelho,
Rafael Soares Diniz,
Joicy Cortez de Sá,
Maria Carmen Fontoura Nogueira da Cruz,
Marco Aurelio Beninni Paschoal,
Letícia Machado Gonçalves

Published: June 5, 2018
https://doi.org/10.1371/journal.pone.0198697

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