Preclinical characterization of the JAK/STAT inhibitor SGI-1252 on skeletal muscle function, morphology, and satellite cell content

Jacob R. Sorensen; Jordan D. Fuqua; Michael R. Deyhle; Jacob Parmley; Caitlin Skousen; Chad Hancock; Allen C. Parcell; Robert D. Hyldahl

doi:10.1371/journal.pone.0198611

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Open Access

Peer-reviewed

Research Article

Preclinical characterization of the JAK/STAT inhibitor SGI-1252 on skeletal muscle function, morphology, and satellite cell content

Jacob R. Sorensen ,

Roles Methodology, Project administration, Writing – original draft

* E-mail: jross.sorensen@gmail.com

Affiliation Department of Exercise Sciences, Brigham Young University, Provo, Utah, United States of America

http://orcid.org/0000-0001-5945-542X

⨯
Jordan D. Fuqua,

Roles Methodology, Project administration, Writing – review & editing

Affiliation Department of Exercise Sciences, Brigham Young University, Provo, Utah, United States of America
⨯
Michael R. Deyhle,

Roles Methodology, Project administration, Writing – review & editing

Affiliation Department of Exercise Sciences, Brigham Young University, Provo, Utah, United States of America
⨯
Jacob Parmley,

Roles Methodology, Project administration

Affiliation Department of Exercise Sciences, Brigham Young University, Provo, Utah, United States of America
⨯
Caitlin Skousen,

Roles Project administration

Affiliation Department of Exercise Sciences, Brigham Young University, Provo, Utah, United States of America
⨯
Chad Hancock,

Roles Conceptualization, Supervision

Affiliation Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, Utah, United States of America

http://orcid.org/0000-0002-1578-5301

⨯
Allen C. Parcell,

Roles Conceptualization, Supervision

Affiliation Department of Exercise Sciences, Brigham Young University, Provo, Utah, United States of America
⨯
Robert D. Hyldahl

Roles Conceptualization, Methodology, Project administration, Supervision, Writing – review & editing

Affiliation Department of Exercise Sciences, Brigham Young University, Provo, Utah, United States of America
⨯

Preclinical characterization of the JAK/STAT inhibitor SGI-1252 on skeletal muscle function, morphology, and satellite cell content

Jacob R. Sorensen,
Jordan D. Fuqua,
Michael R. Deyhle,
Jacob Parmley,
Caitlin Skousen,
Chad Hancock,
Allen C. Parcell,
Robert D. Hyldahl

Published: June 13, 2018
https://doi.org/10.1371/journal.pone.0198611

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Skeletal muscles
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Cell differentiation
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Muscle differentiation
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Myoblasts
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Muscle functions
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Gastrocnemius muscles
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Muscle regeneration
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STAT signaling
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