Genetic abrogation of the fibronectin-α5β1 integrin interaction in articular cartilage aggravates osteoarthritis in mice

Maylin Almonte-Becerril; Irene Gimeno-LLuch; Olga Villarroya; María Benito-Jardón; Juan Bautista Kouri; Mercedes Costell

doi:10.1371/journal.pone.0198559

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Peer-reviewed

Research Article

Genetic abrogation of the fibronectin-α5β1 integrin interaction in articular cartilage aggravates osteoarthritis in mice

Maylin Almonte-Becerril,

Roles Data curation, Formal analysis, Investigation, Writing – original draft

Affiliations Department of Biochemistry and Molecular Biology and Estructura de Reserca Interdisciplinar en Biotecnologia i Biomedicina, Universitat de València, Burjassot, Spain, Departamento de Infectómica y Patogénesis Molecular, Centro de investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), México D.F., México
⨯
Irene Gimeno-LLuch,

Roles Data curation, Formal analysis, Methodology, Writing – original draft

Affiliation Department of Biochemistry and Molecular Biology and Estructura de Reserca Interdisciplinar en Biotecnologia i Biomedicina, Universitat de València, Burjassot, Spain
⨯
Olga Villarroya,

Roles Data curation, Formal analysis

Affiliation Department of Biochemistry and Molecular Biology and Estructura de Reserca Interdisciplinar en Biotecnologia i Biomedicina, Universitat de València, Burjassot, Spain
⨯
María Benito-Jardón,

Roles Data curation, Formal analysis, Investigation, Writing – original draft

Affiliation Department of Biochemistry and Molecular Biology and Estructura de Reserca Interdisciplinar en Biotecnologia i Biomedicina, Universitat de València, Burjassot, Spain
⨯
Juan Bautista Kouri,

Roles Conceptualization, Methodology, Supervision

Affiliation Departamento de Infectómica y Patogénesis Molecular, Centro de investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), México D.F., México
⨯
Mercedes Costell

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: mercedes.costell@uv.es

Affiliation Department of Biochemistry and Molecular Biology and Estructura de Reserca Interdisciplinar en Biotecnologia i Biomedicina, Universitat de València, Burjassot, Spain

http://orcid.org/0000-0001-6146-996X

⨯

Genetic abrogation of the fibronectin-α5β1 integrin interaction in articular cartilage aggravates osteoarthritis in mice

Maylin Almonte-Becerril,
Irene Gimeno-LLuch,
Olga Villarroya,
María Benito-Jardón,
Juan Bautista Kouri,
Mercedes Costell

Published: June 5, 2018
https://doi.org/10.1371/journal.pone.0198559

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Articular cartilage
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Cartilage
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Collagens
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Integrins
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Extracellular matrix
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Safranin staining
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Chondrocytes
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Proteoglycans
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