Loss of murine Gfi1 causes neutropenia and induces osteoporosis depending on the pathogen load and systemic inflammation

• Sven Geissler,

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliations Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Berlin, Germany, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Julius Wolff Institute, Berlin, Germany

  http://orcid.org/0000-0002-8750-6324

  ⨯
• Martin Textor,

  Roles Investigation

  Affiliations Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Berlin, Germany, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Julius Wolff Institute, Berlin, Germany

  ⨯
• Sabine Stumpp,

  Roles Investigation

  Affiliation Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute for Medical Genetics and Human Genetics, Berlin, Germany

  ⨯
• Sebastian Seitz,

  Roles Investigation

  Affiliation University Medical Center Hamburg-Eppendorf, Department of Orthopaedics, Hamburg, Germany

  ⨯
• Anja Lekaj,

  Roles Investigation

  Affiliation Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute for Medical Genetics and Human Genetics, Berlin, Germany

  ⨯
• Sabrina Brunk,

  Roles Investigation

  Affiliation Institut für Tierpathologie, Berlin, Germany

  ⨯
• Sabine Klaassen,

  Roles Writing – review & editing

  Affiliations Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max-Delbrück-Center for Molecular Medicine, Berlin, Germany, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Pediatric Cardiology, Berlin, Germany

  ⨯
• Thorsten Schinke,

  Roles Resources

  Affiliation University Medical Center Hamburg-Eppendorf, Department of Osteology and Biomechanics, Hamburg, Germany

  ⨯
• Christoph Klein,

  Roles Resources

  Affiliation Dr. von Hauner Children’s Hospital, Ludwig Maximilians University, Department of Pediatrics, Munich, Germany

  ⨯
• Stefan Mundlos,

  Roles Funding acquisition, Resources, Supervision

  Affiliations Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Berlin, Germany, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute for Medical Genetics and Human Genetics, Berlin, Germany, Max Planck Institute for Molecular Genetics, FG Development & Disease, Berlin, Germany

  ⨯
• Uwe Kornak,

  Roles Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliations Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Berlin, Germany, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute for Medical Genetics and Human Genetics, Berlin, Germany, Max Planck Institute for Molecular Genetics, FG Development & Disease, Berlin, Germany

  ⨯
• Jirko Kühnisch

  Roles Conceptualization, Investigation, Project administration, Writing – original draft, Writing – review & editing

  * E-mail: jirko.kuehnisch@mdc-berlin.de

  Affiliations Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute for Medical Genetics and Human Genetics, Berlin, Germany, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max-Delbrück-Center for Molecular Medicine, Berlin, Germany, Max Planck Institute for Molecular Genetics, FG Development & Disease, Berlin, Germany

  http://orcid.org/0000-0003-4744-5421

  ⨯