Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling

Martin Liss; Michael H. Radke; Jamina Eckhard; Martin Neuenschwander; Vita Dauksaite; Jens-Peter von Kries; Michael Gotthardt

doi:10.1371/journal.pone.0198492

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Open Access

Peer-reviewed

Research Article

Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling

Martin Liss,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Neuromuscular and Cardiovascular Cell Biology, Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany
⨯
Michael H. Radke,

Roles Data curation, Investigation, Methodology, Validation, Visualization

Affiliations Neuromuscular and Cardiovascular Cell Biology, Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany

http://orcid.org/0000-0003-0112-9917

⨯
Jamina Eckhard,

Roles Data curation, Methodology

Affiliation Screening Unit, Leibniz-Institut für Molekulare Pharmakologie, Berlin, Germany
⨯
Martin Neuenschwander,

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Screening Unit, Leibniz-Institut für Molekulare Pharmakologie, Berlin, Germany
⨯
Vita Dauksaite,

Roles Data curation, Formal analysis, Validation, Visualization

Affiliation Neuromuscular and Cardiovascular Cell Biology, Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany
⨯
Jens-Peter von Kries,

Roles Conceptualization, Project administration, Writing – review & editing

Affiliation Screening Unit, Leibniz-Institut für Molekulare Pharmakologie, Berlin, Germany
⨯
Michael Gotthardt

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: gotthardt@mdc-berlin.de

Affiliations Neuromuscular and Cardiovascular Cell Biology, Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany

http://orcid.org/0000-0003-1788-3172

⨯

Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling

Martin Liss,
Michael H. Radke,
Jamina Eckhard,
Martin Neuenschwander,
Vita Dauksaite,
Jens-Peter von Kries,
Michael Gotthardt

Published: June 11, 2018
https://doi.org/10.1371/journal.pone.0198492

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Heart failure
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