Stepwise occlusion of the carotid arteries of the rat: MRI assessment of the effect of donepezil and hypoperfusion-induced brain atrophy and white matter microstructural changes

Gabriella Nyitrai; Tamás Spisák; Zsófia Spisák; Dávid Gajári; Pálma Diószegi; Tamás Zsigmond Kincses; András Czurkó

doi:10.1371/journal.pone.0198265

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Open Access

Peer-reviewed

Research Article

Stepwise occlusion of the carotid arteries of the rat: MRI assessment of the effect of donepezil and hypoperfusion-induced brain atrophy and white matter microstructural changes

Gabriella Nyitrai ,

Roles Conceptualization, Writing – original draft, Writing – review & editing

* E-mail: nyitraige@richter.hu

Affiliation Preclinical Imaging Center, Pharmacology and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary

http://orcid.org/0000-0001-7351-7770

⨯
Tamás Spisák,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Preclinical Imaging Center, Pharmacology and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary
⨯
Zsófia Spisák,

Roles Data curation, Formal analysis, Visualization, Writing – original draft

Affiliation Preclinical Imaging Center, Pharmacology and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary
⨯
Dávid Gajári,

Roles Investigation

Affiliation Preclinical Imaging Center, Pharmacology and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary
⨯
Pálma Diószegi,

Roles Investigation

Affiliation Preclinical Imaging Center, Pharmacology and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary
⨯
Tamás Zsigmond Kincses,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliations Preclinical Imaging Center, Pharmacology and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary, Department of Neurology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary
⨯
András Czurkó

Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

Affiliation Preclinical Imaging Center, Pharmacology and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary
⨯

Stepwise occlusion of the carotid arteries of the rat: MRI assessment of the effect of donepezil and hypoperfusion-induced brain atrophy and white matter microstructural changes

Gabriella Nyitrai,
Tamás Spisák,
Zsófia Spisák,
Dávid Gajári,
Pálma Diószegi,
Tamás Zsigmond Kincses,
András Czurkó

Published: May 31, 2018
https://doi.org/10.1371/journal.pone.0198265

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