Phosphorylated recombinant HSP27 protects the brain and attenuates blood-brain barrier disruption following stroke in mice receiving intravenous tissue-plasminogen activator

Yoshiaki Shimada; Hideki Shimura; Ryota Tanaka; Kazuo Yamashiro; Masato Koike; Yasuo Uchiyama; Takao Urabe; Nobutaka Hattori

doi:10.1371/journal.pone.0198039

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Open Access

Peer-reviewed

Research Article

Phosphorylated recombinant HSP27 protects the brain and attenuates blood-brain barrier disruption following stroke in mice receiving intravenous tissue-plasminogen activator

Yoshiaki Shimada,

Roles Data curation, Formal analysis, Investigation, Software, Visualization, Writing – original draft

Affiliation Department of Neurology, Juntendo University Urayasu Hospital, Chiba, Japan
⨯
Hideki Shimura ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Writing – original draft, Writing – review & editing

* E-mail: miurashimura@yahoo.co.jp

Affiliations Department of Neurology, Juntendo University Urayasu Hospital, Chiba, Japan, Institute for Environment and Gender Specific Medicine, Juntendo University School of Medicine, Chiba, Japan
⨯
Ryota Tanaka,

Roles Conceptualization, Methodology, Project administration, Writing – review & editing

Affiliation Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
⨯
Kazuo Yamashiro,

Roles Formal analysis, Writing – review & editing

Affiliation Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
⨯
Masato Koike,

Roles Investigation, Methodology, Software, Writing – review & editing

Affiliation Department of Cell Biology and Neuroscience, Juntendo University School of Medicine, Tokyo, Japan
⨯
Yasuo Uchiyama,

Roles Writing – review & editing

Affiliations Department of Cell Biology and Neuroscience, Juntendo University School of Medicine, Tokyo, Japan, Department of Cellular and Molecular Neuropathology, Juntendo University Graduate School of Medicine, Tokyo, Japan
⨯
Takao Urabe,

Roles Project administration, Writing – review & editing

Affiliation Department of Neurology, Juntendo University Urayasu Hospital, Chiba, Japan
⨯
Nobutaka Hattori

Roles Supervision, Writing – review & editing

Affiliation Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
⨯

Phosphorylated recombinant HSP27 protects the brain and attenuates blood-brain barrier disruption following stroke in mice receiving intravenous tissue-plasminogen activator

Yoshiaki Shimada,
Hideki Shimura,
Ryota Tanaka,
Kazuo Yamashiro,
Masato Koike,
Yasuo Uchiyama,
Takao Urabe,
Nobutaka Hattori

Published: May 24, 2018
https://doi.org/10.1371/journal.pone.0198039

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Hemorrhage
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Brain damage
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Ischemic stroke
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Blood-brain barrier
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Reperfusion
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Cerebral ischemia
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Endothelial cells
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Intravenous injections
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