Automated IS6110-based fingerprinting of Mycobacterium tuberculosis: Reaching unprecedented discriminatory power and versatility

Naira Dekhil; Mohamed Amine Skhairia; Besma Mhenni; Saloua Ben Fradj; Rob Warren; Helmi Mardassi

doi:10.1371/journal.pone.0197913

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Open Access

Peer-reviewed

Research Article

Automated IS6110-based fingerprinting of Mycobacterium tuberculosis: Reaching unprecedented discriminatory power and versatility

Naira Dekhil,

Roles Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliation Unit of Typing & Genetics of Mycobacteria, Laboratory of Molecular Microbiology, Vaccinology, and Biotechnology Development, Institut Pasteur de Tunis, Université de Tunis El Manar, Tunis, Tunisia
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Mohamed Amine Skhairia,

Roles Investigation, Methodology, Validation

Affiliation Unit of Typing & Genetics of Mycobacteria, Laboratory of Molecular Microbiology, Vaccinology, and Biotechnology Development, Institut Pasteur de Tunis, Université de Tunis El Manar, Tunis, Tunisia
⨯
Besma Mhenni,

Roles Investigation, Methodology

Affiliation Unit of Typing & Genetics of Mycobacteria, Laboratory of Molecular Microbiology, Vaccinology, and Biotechnology Development, Institut Pasteur de Tunis, Université de Tunis El Manar, Tunis, Tunisia
⨯
Saloua Ben Fradj,

Roles Investigation, Methodology

Affiliation Unit of Typing & Genetics of Mycobacteria, Laboratory of Molecular Microbiology, Vaccinology, and Biotechnology Development, Institut Pasteur de Tunis, Université de Tunis El Manar, Tunis, Tunisia
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Rob Warren,

Roles Resources, Validation, Writing – review & editing

Affiliation DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa
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Helmi Mardassi

Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: helmi.merdassi@pasteur.rns.tn

Affiliation Unit of Typing & Genetics of Mycobacteria, Laboratory of Molecular Microbiology, Vaccinology, and Biotechnology Development, Institut Pasteur de Tunis, Université de Tunis El Manar, Tunis, Tunisia

http://orcid.org/0000-0002-0026-0764

⨯

Automated IS6110-based fingerprinting of Mycobacterium tuberculosis: Reaching unprecedented discriminatory power and versatility

Naira Dekhil,
Mohamed Amine Skhairia,
Besma Mhenni,
Saloua Ben Fradj,
Rob Warren,
Helmi Mardassi

Published: June 1, 2018
https://doi.org/10.1371/journal.pone.0197913

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Restriction fragment length polymorphism analysis
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Tuberculosis
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Polymerase chain reaction
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Mycobacterium tuberculosis
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Extensively drug-resistant tuberculosis
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Blunt-end ligation
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