Discovery and translation of a target engagement marker for AMP-activated protein kinase (AMPK)

Rolf Grempler; Michael Wolff; Eric Simon; Ramona Schmid; Claudia Eisele; Kathrin Rieber; Elke Fischer; Sonja Mettel; Ogsen Gabrielyan; Denis Delic; Gerd Luippold; Norbert Redeman

doi:10.1371/journal.pone.0197849

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Open Access

Peer-reviewed

Research Article

Discovery and translation of a target engagement marker for AMP-activated protein kinase (AMPK)

Rolf Grempler ,

Roles Conceptualization, Data curation, Formal analysis, Supervision, Writing – original draft, Writing – review & editing

* E-mail: rolf.grempler@boehringer-ingelheim.com

Affiliation Department of Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

http://orcid.org/0000-0002-9291-4947

⨯
Michael Wolff,

Roles Data curation, Formal analysis, Supervision, Writing – original draft, Writing – review & editing

Affiliation Department of Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany
⨯
Eric Simon,

Roles Data curation, Formal analysis, Investigation, Writing – original draft

Affiliation Department of Target Discovery Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany
⨯
Ramona Schmid,

Roles Formal analysis, Writing – original draft

Affiliation Department of Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany
⨯
Claudia Eisele,

Roles Data curation, Formal analysis, Methodology, Writing – original draft

Affiliation Department of Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany
⨯
Kathrin Rieber,

Roles Data curation, Formal analysis, Methodology, Writing – original draft

Affiliation Department of Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany
⨯
Elke Fischer,

Roles Data curation, Methodology

Affiliation Department of Cardio Metabolic Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany
⨯
Sonja Mettel,

Roles Data curation, Methodology

Affiliation Department of Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany
⨯
Ogsen Gabrielyan,

Roles Data curation, Formal analysis, Methodology

Affiliation Department of Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany
⨯
Denis Delic,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft

Affiliation Department of Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany
⨯
Gerd Luippold,

Roles Conceptualization, Data curation, Formal analysis, Writing – original draft

Affiliation Department of Cardio Metabolic Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany
⨯
Norbert Redeman

Roles Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Department of Cardio Metabolic Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany
⨯

Discovery and translation of a target engagement marker for AMP-activated protein kinase (AMPK)

Rolf Grempler,
Michael Wolff,
Eric Simon,
Ramona Schmid,
Claudia Eisele,
Kathrin Rieber,
Elke Fischer,
Sonja Mettel,
Ogsen Gabrielyan,
Denis Delic

Published: May 25, 2018
https://doi.org/10.1371/journal.pone.0197849

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