Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase interaction

• Yuta Tsukamoto,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliations Laboratory of Molecular Genetics, Department of Virus Research, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan, Institute of Molecular Medicine, University Hospital Bonn, University of Bonn, Bonn, Germany

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• Sotaro Ikeda,

  Roles Methodology

  Affiliations Laboratory of Molecular Genetics, Department of Virus Research, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan, Laboratory of Molecular and Cellular Immunology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan

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• Koji Uwai,

  Roles Resources, Writing – review & editing

  Affiliation Division of Sustainable and Environmental Engineering, Graduate School of Engineering, Muroran Institute of Technology, Muroran, Japan

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• Riho Taguchi,

  Roles Resources

  Affiliation Division of Sustainable and Environmental Engineering, Graduate School of Engineering, Muroran Institute of Technology, Muroran, Japan

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• Kazuaki Chayama,

  Roles Resources

  Affiliations Department of Gastroenterology and Metabolism, Applied Life Science, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, Japan, Liver Research Project Center, Hiroshima University, Hiroshima, Japan

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• Takemasa Sakaguchi,

  Roles Resources

  Affiliation Department of Virology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

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• Ryo Narita,

  Roles Methodology

  Affiliations Laboratory of Molecular Genetics, Department of Virus Research, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan, Centre for Structural Biology, Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark

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• Wan-Ling Yao,

  Roles Methodology

  Affiliations Laboratory of Molecular Genetics, Department of Virus Research, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan, Laboratory of Molecular and Cellular Immunology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan

  http://orcid.org/0000-0001-6193-9247

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• Fumihiko Takeuchi,

  Roles Methodology

  Affiliations Laboratory of Molecular Genetics, Department of Virus Research, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan, Laboratory of Molecular and Cellular Immunology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan

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• Yukie Otakaki,

  Roles Methodology

  Affiliations Laboratory of Molecular Genetics, Department of Virus Research, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan, Laboratory of Molecular and Cellular Immunology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan

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• Koichi Watashi,

  Roles Resources, Writing – review & editing

  Affiliations Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan, Department of Applied Biological Science, Tokyo University of Science, Noda, Japan, CREST, Japan Science and Technology Agency (JST), Saitama, Japan

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• Takaji Wakita,

  Roles Resources

  Affiliation Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan

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• Hiroki Kato,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliations Laboratory of Molecular Genetics, Department of Virus Research, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan, Institute of Molecular Medicine, University Hospital Bonn, University of Bonn, Bonn, Germany, Laboratory of Molecular and Cellular Immunology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan

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• Takashi Fujita

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: tfujita@virus.kyoto-u.ac.jp

  Affiliations Laboratory of Molecular Genetics, Department of Virus Research, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan, Laboratory of Molecular and Cellular Immunology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan

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