Robotic selection for the rapid development of stable CHO cell lines for HIV vaccine production

Sara M. O’Rourke; Gabriel Byrne; Gwen Tatsuno; Meredith Wright; Bin Yu; Kathryn A. Mesa; Rachel C. Doran; David Alexander; Phillip W. Berman

doi:10.1371/journal.pone.0197656

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Open Access

Peer-reviewed

Research Article

Robotic selection for the rapid development of stable CHO cell lines for HIV vaccine production

Sara M. O’Rourke,

Roles Conceptualization, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Biomolecular Engineering, The University of California at Santa Cruz, Santa Cruz, California, United States of America

http://orcid.org/0000-0001-8624-0483

⨯
Gabriel Byrne,

Roles Resources

Affiliation Department of Biomolecular Engineering, The University of California at Santa Cruz, Santa Cruz, California, United States of America

http://orcid.org/0000-0003-4369-8739

⨯
Gwen Tatsuno,

Roles Methodology

Affiliation Department of Biomolecular Engineering, The University of California at Santa Cruz, Santa Cruz, California, United States of America
⨯
Meredith Wright,

Roles Validation

Affiliation Department of Biomolecular Engineering, The University of California at Santa Cruz, Santa Cruz, California, United States of America
⨯
Bin Yu,

Roles Investigation

Affiliation Department of Biomolecular Engineering, The University of California at Santa Cruz, Santa Cruz, California, United States of America

http://orcid.org/0000-0002-3705-0453

⨯
Kathryn A. Mesa,

Roles Resources

Affiliation Department of Biomolecular Engineering, The University of California at Santa Cruz, Santa Cruz, California, United States of America
⨯
Rachel C. Doran,

Roles Writing – review & editing

Affiliation Department of Biomolecular Engineering, The University of California at Santa Cruz, Santa Cruz, California, United States of America
⨯
David Alexander,

Roles Resources

Affiliation Department of Biomolecular Engineering, The University of California at Santa Cruz, Santa Cruz, California, United States of America
⨯
Phillip W. Berman

Roles Conceptualization, Funding acquisition, Project administration, Resources, Writing – review & editing

* E-mail: pwb@soe.ucsc.edu

Affiliation Department of Biomolecular Engineering, The University of California at Santa Cruz, Santa Cruz, California, United States of America
⨯

Robotic selection for the rapid development of stable CHO cell lines for HIV vaccine production

Sara M. O’Rourke,
Gabriel Byrne,
Gwen Tatsuno,
Meredith Wright,
Bin Yu,
Kathryn A. Mesa,
Rachel C. Doran,
David Alexander,
Phillip W. Berman

Published: August 2, 2018
https://doi.org/10.1371/journal.pone.0197656
See the preprint

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CHO cells
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HIV vaccines
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Transfection
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Vaccine development
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Cell binding
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Enzyme-linked immunoassays
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Glycosylation
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Antibodies
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