Interferon lambda is required for interferon gamma-expressing NK cell responses but does not afford antiviral protection during acute and persistent murine cytomegalovirus infection

Silvia Gimeno Brias; Morgan Marsden; Jessica Forbester; Mathew Clement; Cordelia Brandt; Katherine Harcourt; Leanne Kane; Lucy Chapman; Simon Clare; Ian R. Humphreys

doi:10.1371/journal.pone.0197596

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Open Access

Peer-reviewed

Research Article

Interferon lambda is required for interferon gamma-expressing NK cell responses but does not afford antiviral protection during acute and persistent murine cytomegalovirus infection

Silvia Gimeno Brias,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Institute of Infection Immunity, School of Medicine/Systems Immunity University Research Institute, Cardiff University, Cardiff, United Kingdom
⨯
Morgan Marsden,

Roles Methodology, Project administration

Affiliation Institute of Infection Immunity, School of Medicine/Systems Immunity University Research Institute, Cardiff University, Cardiff, United Kingdom
⨯
Jessica Forbester,

Roles Investigation, Methodology, Writing – review & editing

Affiliations Institute of Infection Immunity, School of Medicine/Systems Immunity University Research Institute, Cardiff University, Cardiff, United Kingdom, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom
⨯
Mathew Clement,

Roles Investigation, Writing – review & editing

Affiliation Institute of Infection Immunity, School of Medicine/Systems Immunity University Research Institute, Cardiff University, Cardiff, United Kingdom
⨯
Cordelia Brandt,

Roles Investigation

Affiliation Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom
⨯
Katherine Harcourt,

Roles Investigation

Affiliation Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom
⨯
Leanne Kane,

Roles Investigation

Affiliation Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom
⨯
Lucy Chapman,

Roles Methodology

Affiliation Institute of Infection Immunity, School of Medicine/Systems Immunity University Research Institute, Cardiff University, Cardiff, United Kingdom
⨯
Simon Clare,

Roles Conceptualization, Investigation, Project administration, Supervision, Writing – review & editing

Affiliation Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom
⨯
Ian R. Humphreys

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: humphreysir@cardiff.ac.uk

Affiliations Institute of Infection Immunity, School of Medicine/Systems Immunity University Research Institute, Cardiff University, Cardiff, United Kingdom, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom

http://orcid.org/0000-0002-9512-5337

⨯

Interferon lambda is required for interferon gamma-expressing NK cell responses but does not afford antiviral protection during acute and persistent murine cytomegalovirus infection

Silvia Gimeno Brias,
Morgan Marsden,
Jessica Forbester,
Mathew Clement,
Cordelia Brandt,
Katherine Harcourt,
Leanne Kane,
Lucy Chapman,
Simon Clare,
Ian R. Humphreys

Published: May 16, 2018
https://doi.org/10.1371/journal.pone.0197596

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NK cells
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Cytomegalovirus infection
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Viral replication
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Human cytomegalovirus
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T cells
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Antiviral immune response
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