Biophotonic detection of high order chromatin alterations in field carcinogenesis predicts risk of future hepatocellular carcinoma: A pilot study

Richard Kalman; Andrew Stawarz; David Nunes; Di Zhang; Mart A. Dela Cruz; Arpan Mohanty; Hariharan Subramanian; Vadim Backman; Hemant K. Roy

doi:10.1371/journal.pone.0197427

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Open Access

Peer-reviewed

Research Article

Biophotonic detection of high order chromatin alterations in field carcinogenesis predicts risk of future hepatocellular carcinoma: A pilot study

Richard Kalman ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

* E-mail: rskalman@gmail.com

Affiliation Department of Medicine, Einstein Medical Center, Philadelphia, Pennsylvania, United States of America

http://orcid.org/0000-0002-2248-5032

⨯
Andrew Stawarz,

Roles Conceptualization, Data curation, Investigation

Affiliation Biomedical Engineering Department, Northwestern University, Evanston, Illinois, United States of America
⨯
David Nunes,

Roles Conceptualization, Supervision

Affiliation Department of Medicine, Boston University Medical Center, Boston, Massachusetts, United States of America
⨯
Di Zhang,

Roles Investigation

Affiliation Biomedical Engineering Department, Northwestern University, Evanston, Illinois, United States of America
⨯
Mart A. Dela Cruz,

Roles Investigation

Affiliation Department of Medicine, Boston University Medical Center, Boston, Massachusetts, United States of America
⨯
Arpan Mohanty,

Roles Investigation

Affiliation Department of Medicine, Boston University Medical Center, Boston, Massachusetts, United States of America
⨯
Hariharan Subramanian,

Roles Data curation, Formal analysis, Investigation, Resources, Software

Affiliation Biomedical Engineering Department, Northwestern University, Evanston, Illinois, United States of America
⨯
Vadim Backman,

Roles Conceptualization, Funding acquisition

Affiliation Biomedical Engineering Department, Northwestern University, Evanston, Illinois, United States of America
⨯
Hemant K. Roy

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

Affiliation Department of Medicine, Boston University Medical Center, Boston, Massachusetts, United States of America
⨯

Biophotonic detection of high order chromatin alterations in field carcinogenesis predicts risk of future hepatocellular carcinoma: A pilot study

Richard Kalman,
Andrew Stawarz,
David Nunes,
Di Zhang,
Mart A. Dela Cruz,
Arpan Mohanty,
Hariharan Subramanian,
Vadim Backman,
Hemant K. Roy

Published: May 17, 2018
https://doi.org/10.1371/journal.pone.0197427

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Hepatocellular carcinoma
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Biopsy
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Carcinogenesis
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Chromatin
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Cirrhosis
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Lung and intrathoracic tumors
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