Complex interactions in a novel SCN5A compound mutation associated with long QT and Brugada syndrome: Implications for Na⁺ channel blocking pharmacotherapy for de novo conduction disease

• Jie Liu,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliation Department of Biology, York University, Toronto, Ontario, Canada

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• Jason D. Bayer,

  Roles Formal analysis, Methodology, Software, Validation, Writing – original draft, Writing – review & editing

  Affiliations Electrophysiology and Heart Modeling Institute (LIRYC), Bordeaux University Foundation, Pessac, France, University of Bordeaux, IMB, UMR 5251, Talance, France

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• Roozbeh Aschar-Sobbi,

  Roles Formal analysis, Methodology

  Affiliation Department of Biology, York University, Toronto, Ontario, Canada

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• Marianne Wauchop,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Department of Biology, York University, Toronto, Ontario, Canada

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• Danna Spears,

  Roles Data curation

  Affiliation Peter Munk Cardiac Center, Division of Cardiology, University Health Network, Toronto, Ontario, Canada

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• Michael Gollob,

  Roles Data curation, Methodology, Resources, Writing – review & editing

  Affiliation Peter Munk Cardiac Center, Division of Cardiology, University Health Network, Toronto, Ontario, Canada

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• Edward J. Vigmond,

  Roles Formal analysis, Investigation, Methodology, Software, Supervision, Writing – review & editing

  Affiliations Electrophysiology and Heart Modeling Institute (LIRYC), Bordeaux University Foundation, Pessac, France, University of Bordeaux, IMB, UMR 5251, Talance, France

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• Robert Tsushima,

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources

  Affiliation Department of Biology, York University, Toronto, Ontario, Canada

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• Peter H. Backx ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: pbackx@YORKU.ca (PB); vijay.chauhan@uhn.ca (VC)

  Affiliations Department of Biology, York University, Toronto, Ontario, Canada, Peter Munk Cardiac Center, Division of Cardiology, University Health Network, Toronto, Ontario, Canada

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• Vijay S. Chauhan

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: pbackx@YORKU.ca (PB); vijay.chauhan@uhn.ca (VC)

  Affiliation Peter Munk Cardiac Center, Division of Cardiology, University Health Network, Toronto, Ontario, Canada

  http://orcid.org/0000-0001-9264-5073

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