A multi-center preclinical study of gadoxetate DCE-MRI in rats as a biomarker of drug induced inhibition of liver transporter function

• Anastassia Karageorgis ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: anastassia.karageorgis@hotmail.fr

  Affiliation Safety and ADME Translational Sciences, Drug Safety and Metabolism, AstraZeneca, Gothenburg, Sweden

  http://orcid.org/0000-0003-1348-5580

  ⨯
• Stephen C. Lenhard,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Bioimaging, Platform Technology and Sciences, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America

  ⨯
• Brittany Yerby,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Research Imaging Sciences, Amgen, Thousand Oaks, California, United States of America

  ⨯
• Mikael F. Forsgren,

  Roles Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Center for Medical Image Science and Visualization (CMIV), Department of Medical and Health Sciences, Linköping University, Linköping, Sweden, Wolfram MathCore, Linköping, Sweden

  ⨯
• Serguei Liachenko,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliation National Center for Toxicological Research, Division of Neurotoxicology, United States Food and Drug Administration, Jefferson, Arkansas, United States of America

  ⨯
• Edvin Johansson,

  Roles Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Personalised Healthcare and Biomarkers, Imaging group, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Gothenburg, Sweden

  ⨯
• Mark A. Pilling,

  Roles Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Biostatistics, Quantitative Biology, Discovery Sciences, Innovative Medicines and Early Development, AstraZeneca R&D, Cambridge, United Kingdom

  ⨯
• Richard A. Peterson,

  Roles Formal analysis, Investigation

  Affiliation Safety Assessment, GlaxoSmithKline, Research Triangle Park, Durham, North Carolina, United States of America

  ⨯
• Xi Yang,

  Roles Formal analysis, Investigation

  Affiliation National Center for Toxicological Research, Division of Systems Biology, United States Food and Drug Administration, Jefferson, Arkansas, United States of America

  ⨯
• Dominic P. Williams,

  Roles Methodology, Writing – original draft, Writing – review & editing

  Affiliation Safety and ADME Translational Sciences, Drug Safety and Metabolism, AstraZeneca, Cambridge, United Kingdom

  ⨯
• Sharon E. Ungersma,

  Roles Conceptualization, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Research Imaging Sciences, Amgen, Thousand Oaks, California, United States of America

  ⨯
• Ryan E. Morgan,

  Roles Conceptualization, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Comparative Biology and Safety Sciences, Amgen Inc., Thousand Oaks, California, United States of America

  ⨯
• Kim L. R. Brouwer,

  Roles Conceptualization, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of N orth Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

  ⨯
• Beat M. Jucker,

  Roles Conceptualization, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Bioimaging, Platform Technology and Sciences, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America

  ⨯
• Paul D. Hockings

  Roles Conceptualization, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Antaros Medical, BioVenture Hub, Mölndal, Sweden, MedTech West, Chalmers University of Technology, Gothenburg, Sweden

  ⨯