Early changes in rpS6 phosphorylation and BH3 profiling predict response to chemotherapy in AML cells

Martin Grundy; Thomas Jones; Liban Elmi; Michael Hall; Adam Graham; Nigel Russell; Monica Pallis

doi:10.1371/journal.pone.0196805

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Open Access

Peer-reviewed

Research Article

Early changes in rpS6 phosphorylation and BH3 profiling predict response to chemotherapy in AML cells

Martin Grundy ,

Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

* E-mail: m.grundy@nottingham.ac.uk

Affiliation Clinical Haematology, Nottingham University Hospitals, Nottingham, United Kingdom

http://orcid.org/0000-0002-0719-2469

⨯
Thomas Jones,

Roles Data curation, Investigation, Methodology, Writing – review & editing

Current address: Academic Unit of Molecular Oncology, Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom

Affiliation Department of Haematology, Division of Cancer and Stem Cells, University of Nottingham, Nottingham, United Kingdom
⨯
Liban Elmi,

Roles Data curation, Investigation, Writing – review & editing

Affiliation Department of Haematology, Division of Cancer and Stem Cells, University of Nottingham, Nottingham, United Kingdom
⨯
Michael Hall,

Roles Data curation, Investigation, Writing – review & editing

Affiliation Department of Haematology, Division of Cancer and Stem Cells, University of Nottingham, Nottingham, United Kingdom
⨯
Adam Graham,

Roles Data curation, Investigation, Writing – review & editing

Affiliation Department of Haematology, Division of Cancer and Stem Cells, University of Nottingham, Nottingham, United Kingdom
⨯
Nigel Russell,

Roles Funding acquisition, Supervision

Affiliations Clinical Haematology, Nottingham University Hospitals, Nottingham, United Kingdom, Department of Haematology, Division of Cancer and Stem Cells, University of Nottingham, Nottingham, United Kingdom
⨯
Monica Pallis

Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

Affiliation Clinical Haematology, Nottingham University Hospitals, Nottingham, United Kingdom
⨯

Early changes in rpS6 phosphorylation and BH3 profiling predict response to chemotherapy in AML cells

Martin Grundy,
Thomas Jones,
Liban Elmi,
Michael Hall,
Adam Graham,
Nigel Russell,
Monica Pallis

Published: May 3, 2018
https://doi.org/10.1371/journal.pone.0196805

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